Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 14/20 | 0.97 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.66 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.66 |
| ▸ | EGFR | P00533 | 2/20 | 0.66 |
| ▸ | MTOR | P42345 | 2/20 | 0.66 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.66 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.66 |
| ▸ | PDXK | O00764 | 1/20 | 0.66 |
| ▸ | GAK | O14976 | 1/20 | 0.66 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.66 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.66 |
| ▸ | STK16 | O75716 | 1/20 | 0.66 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.66 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.66 |
| ▸ | OXSR1 | O95747 | 1/20 | 0.66 |
| ▸ | LATS1 | O95835 | 1/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3737062 | 0.99 | PIK3CG (1.00) | PIK3CGPIK3CAPIK3CBPIK3CDABL1 | |
| Hydrochloric Acid SCHEMBL3537202 | 0.97 | PIK3CG (0.97) | PIK3CGPIK3CAPIK3CBPIK3CDABL1 | |
| SCHEMBL3745260 | 0.90 | PIK3CG (0.83) | PIK3CGPIK3CAPIK3CBPIK3CDABL1 | |
| Tg100-115 SCHEMBL3539251 | 0.81 | PIK3CG (0.97) | PIK3CGPIK3CAPIK3CBPIK3CDABL1 | |
| Tg100-115 SCHEMBL3539255 | 0.81 | PIK3CG (0.97) | PIK3CGPIK3CAPIK3CBPIK3CDABL1 | |
| SCHEMBL3532692 | 0.80 | PIK3CG (1.00) | PIK3CGPIK3CAPIK3CBPIK3CDABL1 | |
| SCHEMBL3742316 | 0.80 | ADK (0.76) | PIK3CGPIK3CAPIK3CBPIK3CDMTOR | |
| SCHEMBL3533560 | 0.79 | PIK3CG (1.00) | PIK3CGPIK3CAPIK3CBPIK3CDABL1 | |
| Tg100-115 SCHEMBL29506727 | 0.79 | PIK3CG (1.00) | PIK3CGPIK3CAPIK3CBPIK3CDABL1 | |
| Tg100-115 SCHEMBL31238338 | 0.79 | PIK3CG (1.00) | PIK3CGPIK3CAPIK3CBPIK3CDABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2039683-B1 | Vasculostatic agents and methods of use thereof | TARGEGEN INC (US) | 2012-12-19 | — | — | EP | disclosed |
| EP-2039683-A2 | Vasculostatic agents and methods of use thereof | Targegen, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |