Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 7/20 | 0.40 |
| ▸ | AURKA | O14965 | 5/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4362898 | 0.92 | AURKB (0.39) | AURKBAURKAHDAC1HDAC2HDAC6 | |
| SCHEMBL4362895 | 0.91 | AURKB (0.37) | AURKBAURKAHDAC1HDAC2HDAC6 | |
| SCHEMBL13785498 | 0.87 | AURKA (0.47) | AURKBAURKA | |
| SCHEMBL13785504 | 0.87 | AURKA (0.47) | AURKBAURKA | |
| SCHEMBL4530762 | 0.83 | AURKA (0.44) | AURKBAURKA | |
| SCHEMBL13785508 | 0.83 | AURKA (0.44) | AURKBAURKA | |
| SCHEMBL13785495 | 0.79 | AURKA (0.48) | AURKBAURKA | |
| SCHEMBL4570009 | 0.79 | AURKA (0.51) | AURKBAURKA | |
| SCHEMBL4373208 | 0.77 | AURKA (0.48) | AURKBAURKA | |
| SCHEMBL13785491 | 0.77 | AURKA (0.47) | AURKBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009086012-A1 | AURORA INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |