Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 6/20 | 0.39 |
| ▸ | AURKA | O14965 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4362908 | 0.92 | AURKB (0.40) | AURKBAURKAHDAC1HDAC6HDAC2 | |
| SCHEMBL4362895 | 0.89 | AURKB (0.37) | AURKBAURKAHDAC1HDAC6HDAC2 | |
| SCHEMBL13785504 | 0.85 | AURKA (0.47) | AURKBAURKA | |
| SCHEMBL13785498 | 0.85 | AURKA (0.47) | AURKBAURKA | |
| SCHEMBL4362432 | 0.83 | AURKB (0.47) | AURKBAURKAHDAC1HDAC6HDAC2 | |
| SCHEMBL4368646 | 0.83 | AURKB (0.47) | AURKBAURKAHDAC1HDAC6HDAC2 | |
| SCHEMBL4363095 | 0.82 | AURKB (0.47) | AURKBAURKAHDAC1HDAC6HDAC2 | |
| SCHEMBL4530762 | 0.81 | AURKA (0.44) | AURKBAURKA | |
| SCHEMBL13785508 | 0.81 | AURKA (0.44) | AURKBAURKA | |
| SCHEMBL4370921 | 0.81 | AURKB (0.48) | AURKBAURKAHDAC1HDAC6HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009086012-A1 | AURORA INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |