Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4365027 | 1.00 | EGFR (0.36) | EGFRPTPN11ALDH1A1GRM5FGFR3 | |
| SCHEMBL2518035 | 0.87 | IDO1 (0.39) | EGFRPTPN11ALDH1A1 | |
| SCHEMBL2518029 | 0.87 | IDO1 (0.39) | EGFRPTPN11ALDH1A1 | |
| SCHEMBL4365029 | 0.78 | IDO1 (0.46) | — | |
| SCHEMBL6046563 | 0.74 | IDO1 (0.41) | ALDH1A1 | |
| SCHEMBL6046562 | 0.74 | IDO1 (0.41) | ALDH1A1 | |
| SCHEMBL12053017 | 0.73 | EGFR (0.37) | EGFRPTPN11ALDH1A1KDRHAO1 | |
| SCHEMBL2515556 | 0.72 | IDO1 (0.42) | EGFR | |
| SCHEMBL2515541 | 0.72 | IDO1 (0.42) | EGFR | |
| SCHEMBL4980790 | 0.70 | ALDH1A1 (0.45) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879573-A4 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | INCYTE CORP (US) | 2009-07-08 | — | — | EP | claimed |
| EP-1879573-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | Incyte Corporation (US) | 2008-01-23 | — | — | EP | claimed |
| WO-2006122150-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2006-11-16 | — | — | WO | claimed |