Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 13/20 | 0.77 |
| ▸ | CTSS | P25774 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5941473 | 1.00 | CTSK (0.77) | CTSKCTSSMAPK1ALDH1A1LMNA | |
| SCHEMBL4048050 | 0.90 | CTSK (0.75) | CTSKCTSSCCR1POLB | |
| SCHEMBL4041814 | 0.89 | CTSK (0.79) | CTSKCTSSALDH1A1MEN1KMT2A | |
| SCHEMBL4039416 | 0.88 | CTSK (0.78) | CTSKCTSSALDH1A1MEN1KMT2A | |
| SCHEMBL4041202 | 0.88 | CTSK (0.80) | CTSKCTSSCCR1POLB | |
| SCHEMBL4040161 | 0.88 | CTSK (0.74) | CTSKCTSSCCR1POLB | |
| SCHEMBL4224757 | 0.88 | CTSK (0.77) | CTSKCTSSALDH1A1MEN1KMT2A | |
| SCHEMBL4038929 | 0.88 | CTSK (0.77) | CTSKCTSSALDH1A1MEN1KMT2A | |
| SCHEMBL4042931 | 0.88 | CTSK (0.77) | CTSKCTSSCCR1 | |
| SCHEMBL4048538 | 0.88 | CTSK (0.77) | CTSKCTSSALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |