Citric Acid

Citric Acid

SCHEMBL43667

O=C([O-])CC(O)(CC(=O)O)C(=O)[O-].[Na+].[Na+]

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1GSK3AGSK3BHRH1HRH2HTR7IDH1IDH2IMPA1IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CA4 P22748 2/20 0.81
ALDH1A1 P00352 1/20 0.50
HMGCR P04035 1/20 0.39
CHRM1 P11229 1/20 0.39
TBXA2R P21731 1/20 0.39
ADRA1A P35348 1/20 0.39
ACLY P53396 3/20 0.32
CYP2D6 P10635 1/20 0.32
TSHR P16473 1/20 0.32
CYP2C19 P33261 1/20 0.32
HIF1A Q16665 1/20 0.32
CASP1 P29466 1/20 0.32
CPT2 P23786 1/20 0.31
SLC13A5 Q86YT5 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL9004291 1.00 CA4 (0.81) CA4ALDH1A1HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL28693270 1.00 CA4 (0.81) CA4ALDH1A1HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL27897065 1.00 CA4 (0.81) CA4ALDH1A1HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL28519870 0.98 CA4 (0.77) CA4ALDH1A1HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL4362561 0.98 CA4 (0.77) CA4ALDH1A1HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL4733350 0.98 CA4 (0.77) CA4ALDH1A1HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL365961 0.98 CA4 (0.77) CA4ALDH1A1HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL2572858 0.98 CA4 (0.77) CA4ALDH1A1HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL13684440 0.98 CA4 (0.77) CA4ALDH1A1HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL73056 0.98 CA4 (0.77) CA4ALDH1A1HMGCRCHRM1TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 9681 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-121805475-B Detection method of bromarol diamide in ginger Shandong maker detection Co.,Ltd. (CN) 2026-05-26 CN claimed
US-20260138160-A1 ANTI-FRICTION INTERLEAVING MATERIAL FOR GLASS AND GLASS COATINGS ETAMORPHIC INC (US) 2026-05-21 US claimed
CN-122017257-A Detection method and detection kit for oxidized low-density lipoprotein 济南玖方生物科技有限公司 2026-05-12 CN claimed
US-20260115225-A1 Effervescent Laxative Composition L PERRIGO COMPANY (US) 2026-04-30 US claimed
US-20260108477-A1 CYCLOBENZAPRINE TREATMENT FOR FIBROMYALGIA TONIX PHARMA LTD (IE) 2026-04-23 US claimed
EP-4727587-A1 INJECTABLE COMPOSITE DEPOT DelSiTech Oy (FI) 2026-04-22 EP claimed
EP-4720314-A1 AAV PURIFICATION METHOD Juno Therapeutics, Inc. (US) 2026-04-08 EP claimed
US-12590187-B2 Polymer composite capable of being quickly dissolved or dispersed in aqueous solvent and preparation method and application thereof FUDAN UNIVERSITY (CN) 2026-03-31 US claimed
EP-4707350-A1 TREATMENT LIQUID COMPOSITION FOR DYE PRINTING, INK SET, AND RECORDING METHOD Seiko Epson Corporation (JP) 2026-03-11 EP claimed
EP-3829311-B1 CITRATE PERHYDRATES AND USES THEREOF BIOREM ENG SA (CH) 2026-03-11 EP claimed
US-4444800-A SOLVATION AGENT L.D. SCHREIBER CHEESE CO., INC. (US) 1984-04-24 US claimed
EP-0013783-B1 PROTECTION OF THE GASTRIC MUCOSAL LINING FROM DAMAGE BY ASPIRIN AND RELATED DRUGS THE AUSTRALIAN NATIONAL UNIVERSITY (AU) 1984-04-04 EP claimed
EP-0011489-B1 AN ANALGESIC EFFERVESCENT POWDER AND PROCESS FOR ITS PREPARATION BEECHAM GROUP PLC (GB) 1982-12-15 EP claimed
US-4309408-A ACETAMINOPHEN AND METOCLOPRAMIDE; ANALGESIC FOR MIGRAINE HEADACHES BEECHAM GROUP LIMITED (GB) 1982-01-05 US claimed
US-4268694-A HYDROLYSIS OF TETRAHALOCYCLOHEXANONE FISONS LIMITED (GB) 1981-05-19 US claimed
US-4260452-A DEPITHING, PULPING KRUEGER HORST 1981-04-07 US claimed
EP-0011489-A1 An analgesic effervescent powder and process for its preparation BEECHAM GROUP PLC (GB) 1980-05-28 EP claimed
US-4200586-A Inhibiting the carbon-carbon double bond isomerization of substituted or unsubstituted hydrocarbon compounds PHILLIPS PETROLEUM COMPANY (US) 1980-04-29 US claimed
US-4057615-A Method of tagging excipients with 99M technetium COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 1977-11-08 US claimed
US-4009114-A ALKYL ARYL SULFONATES, ALKALI METAL SILICATES AND CARBONATES COLGATE-PALMOLIVE COMPANY (US) 1977-02-22 US claimed