Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1GSK3AGSK3BHRH1HRH2HTR7IDH1IDH2IMPA1IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL6864505 | 0.98 | CA4 (0.74) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL9004291 | 0.98 | CA4 (0.81) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL43667 | 0.98 | CA4 (0.81) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL475574 | 0.98 | CA4 (0.73) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL28693270 | 0.98 | CA4 (0.81) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL27897065 | 0.98 | CA4 (0.81) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL107371 | 0.95 | CA4 (0.70) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL4733350 | 0.95 | CA4 (0.77) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL365961 | 0.95 | CA4 (0.77) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL4362561 | 0.95 | CA4 (0.77) | CA4ALDH1A1HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 686 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3487916-B1 | FUNCTIONALIZED PARTICULATE BICARBONATE AS BLOWING AGENT, FOAMABLE POLYMER COMPOSITION CONTAINING IT, AND ITS USE IN MANUFACTURING A THERMOPLASTIC FOAMED POLYMER | SOLVAY (BE) | 2025-09-03 | — | — | EP | claimed |
| CN-120059003-A | Low-odor polyvinyl alcohol and preparation method and application thereof | 中国石油化工股份有限公司 | 2025-05-30 | — | — | CN | claimed |
| CN-119465115-A | Chemical thick copper-precipitating composite liquid and preparation method thereof | 惠州金晟新电子科技有限公司 | 2025-02-18 | — | — | CN | claimed |
| CN-118834332-A | Ionic hydrogel, preparation method thereof and application of ionic hydrogel in thermoelectric intelligent color-changing glass | 华南理工大学 | 2024-10-25 | — | — | CN | claimed |
| CN-118806759-A | Systemic formulations of pyridone derivatives for TG2 related diseases | 福尔克博士药物有限责任公司 | 2024-10-22 | — | — | CN | claimed |
| CN-115867260-B | Systemic formulations of pyridone derivatives for celiac disease | 福尔克博士药物有限责任公司 | 2024-10-01 | — | — | CN | claimed |
| EP-3655469-B1 | FUNCTIONALIZED PARTICULATE BICARBONATE AS BLOWING AGENT, FOAMABLE POLYMER COMPOSITION CONTAINING IT, AND ITS USE IN MANUFACTURING A THERMOPLASTIC FOAMED POLYMER | SOLVAY (BE) | 2024-09-25 | — | — | EP | claimed |
| CN-115715187-B | Systemic formulations of pyridone derivatives for TG2 related diseases | 福尔克博士药物有限责任公司 | 2024-07-19 | — | — | CN | claimed |
| EP-3556371-B1 | PHARMACEUTICAL COMPOSITION OF SULFONYLUREA DRUGS AND PREPARATION METHOD THEREFOR | JIANGSU AOSAIKANG PHARM CO LTD (CN) | 2024-06-12 | — | — | EP | claimed |
| CN-118079003-A | Phosphodiesterase type 5 inhibitors for lowering uric acid levels and uses thereof | 海南大学 | 2024-05-28 | — | — | CN | claimed |
| US-5106534-A | Polycarboxylic acid and inorganic carbonate surface treated with component which prevents water absorption | J. M. HUBER CORPORATION (US) | 1992-04-21 | — | — | US | claimed |
| WO-1991016893-A1 | PHARMACEUTICAL FORMULATION | BEECHAM GROUP PLC (GB) | 1991-11-14 | — | — | WO | claimed |
| US-5045570-A | Additives are caused to concentrate at the surface of the foamed article | J. M. HUBER CORPORATION (US) | 1991-09-03 | — | — | US | claimed |
| US-5037580-A | Mixture of surface treated polycarboxylic acid and inorganic carbonate | J. M. HUBER CORPORATION (US) | 1991-08-06 | — | — | US | claimed |
| US-5009810-A | Mixture of polycarboxylic acid and inorganic carbonate surface treated with silane coupling agent, monoglycerides or stearic acid; foaming polymers | J. M. HUBER CORPORATION (US) | 1991-04-23 | — | — | US | claimed |
| US-5009809-A | High temperature endothermic blowing agents compositions and applications | J. M. HUBER CORPORATION (US) | 1991-04-23 | — | — | US | claimed |
| WO-1990014384-A1 | ENDOTHERMIC BLOWING AGENTS COMPOSITIONS AND APPLICATIONS | J.M. HUBER CORPORATION (US) | 1990-11-29 | — | — | WO | claimed |
| EP-0396335-A1 | Pharmaceutical formulation | Beecham Group p.l.c. (GB) | 1990-11-07 | — | — | EP | claimed |
| US-4961927-A | Clear solution containing lysozyme hydrochloride and dipotassium glycyrrhizinate | EISAI CO., LTD. (JP) | 1990-10-09 | — | — | US | claimed |
| US-4200586-A | Inhibiting the carbon-carbon double bond isomerization of substituted or unsubstituted hydrocarbon compounds | PHILLIPS PETROLEUM COMPANY (US) | 1980-04-29 | — | — | US | claimed |