Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Paliperidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 16/20 | 1.00 |
| ▸ | HTR2A known ✓ | P28223 | 15/20 | 1.00 |
| ▸ | HTR2C | P28335 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 3/20 | 1.00 |
| ▸ | HRH1 | P35367 | 3/20 | 1.00 |
| ▸ | HTR7 | P34969 | 3/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 2/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 2/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | DRD4 | P21917 | 2/20 | 1.00 |
| ▸ | DRD5 | P21918 | 2/20 | 1.00 |
| ▸ | HTR1D | P28221 | 2/20 | 1.00 |
| ▸ | HTR1B | P28222 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | SCN5A | Q14524 | 2/20 | 1.00 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 6/20 | 0.75 |
| ▸ | ACHE | P22303 | 3/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paliperidone SCHEMBL11899798 | 1.00 | DRD2 (1.00) | DRD2HTR2AHTR2CKCNH2ADRA1A | |
| Paliperidone SCHEMBL20572022 | 1.00 | DRD2 (1.00) | DRD2HTR2AHTR2CKCNH2ADRA1A | |
| Paliperidone SCHEMBL29409219 | 1.00 | DRD2 (1.00) | DRD2HTR2AHTR2CKCNH2ADRA1A | |
| Paliperidone SCHEMBL29377584 | 1.00 | DRD2 (1.00) | DRD2HTR2AHTR2CKCNH2ADRA1A | |
| Paliperidone SCHEMBL67205 | 1.00 | DRD2 (1.00) | DRD2HTR2AHTR2CKCNH2ADRA1A | |
| Paliperidone SCHEMBL1667922 | 0.99 | DRD2 (0.98) | DRD2HTR2AHTR2CKCNH2ADRA1A | |
| Paliperidone SCHEMBL1831211 | 0.99 | DRD2 (0.98) | DRD2HTR2AHTR2CKCNH2ADRA1A | |
| Paliperidone SCHEMBL1119094 | 0.99 | DRD2 (0.98) | DRD2HTR2AHTR2CKCNH2ADRA1A | |
| Paliperidone SCHEMBL1443676 | 0.99 | DRD2 (0.98) | DRD2HTR2AHTR2CKCNH2ADRA1A | |
| Paliperidone SCHEMBL3074063 | 0.99 | DRD2 (0.98) | DRD2HTR2AHTR2CKCNH2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2205 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12594236-B2 | Method of treating acute exacerbation of schizophrenia with long-acting injectable depot composition | LABORATORIOS FARMACEUTICOS ROVI, S.A. (ES) | 2026-04-07 | — | — | US | claimed |
| US-12318387-B2 | Method of treating acute exacerbation of schizophrenia with long-acting injectable depot composition | LABORATORIOS FARMACEUTICOS ROVI, S.A. (ES) | 2025-06-03 | — | — | US | claimed |
| US-12318478-B2 | Risperidone or paliperidone implant formulation | LABORATORIOS FARMACÉUTICOS ROVI, S.A. (ES) | 2025-06-03 | — | — | US | claimed |
| CN-120044146-A | Method for detecting antipsychotic drugs and metabolites thereof in sample and kit thereof | 瑞莱谱(杭州)医疗科技有限公司 | 2025-05-27 | — | — | CN | claimed |
| CN-115754079-B | Method for simultaneously detecting contents of 7 psychotropic drugs and metabolites thereof | 合肥和合医疗科技有限公司 | 2025-04-04 | — | — | CN | claimed |
| US-20240390270-A1 | GASTRIC RESIDENCE SYSTEMS FOR ADMINISTRATION OF RISPERIDONE | Nortiva Bio, Inc. | 2024-11-28 | — | — | US | claimed |
| CN-115078612-B | Analysis method for detecting chemicals based on modified Cr-MOF | 长沙理工大学 | 2024-08-30 | — | — | CN | claimed |
| CN-113917025-B | Kit for quantitatively detecting psychotropic drugs in biological samples and application of kit | 上海市精神卫生中心（上海市心理咨询培训中心） | 2024-07-19 | — | — | CN | claimed |
| CN-113917024-B | Kit for detecting nine in-vivo psychiatric drugs and metabolites thereof | 上海市精神卫生中心（上海市心理咨询培训中心） | 2024-07-05 | — | — | CN | claimed |
| US-20240148641-A1 | Long Acting Injectable Formulation Comprising Risperidone and Biodegradable Polymers | MEDINCELL S.A. (FR) | 2024-05-09 | — | — | US | claimed |
| EP-0904081-A1 | AQUEOUS SUSPENSIONS OF 9-HYDROXYRISPERIDONE FATTY ACID ESTERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-03-31 | — | — | EP | claimed |
| EP-0904063-A2 | MICROPARTICLES | Alkermes Controlled Therapeutics Inc. II (US) | 1999-03-31 | — | — | EP | claimed |
| US-5792477-A | EMULSIFICATION OF TWO PHASES; SEPARATION; WASHING; REDUCING LEVEL OF RESIDUAL SOLVENT | ALKERMES CONTROLLED THERAPEUTICS, INC. II (US) | 1998-08-11 | — | — | US | claimed |
| US-5770231-A | Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles 1,2-benzisothiazoles | ALKERMES CONTROLLED THERAPEUTICS, INC. II (US) | 1998-06-23 | — | — | US | claimed |
| WO-1997044039-A1 | AQUEOUS SUSPENSIONS OF 9-HYDROXYRISPERIDONE FATTY ACID ESTERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-11-27 | — | — | WO | claimed |
| WO-1997041837-A2 | MICROPARTICLES | ALKERMES CONTROLLED THERAPEUTICS INC. II (US) | 1997-11-13 | — | — | WO | claimed |
| US-5650173-A | Preparation of biodegradable microparticles containing a biologically active agent | ALKERMES CONTROLLED THERAPEUTICS INC. II (US) | 1997-07-22 | — | — | US | claimed |
| EP-0368388-B1 | 3-Piperidinyl-1,2-benzisoxazoles | JANSSEN PHARMACEUTICA NV (BE) | 1995-05-10 | — | — | EP | claimed |
| US-5254556-A | Antipsychotic; paliperidone palmitate | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-10-19 | — | — | US | claimed |
| US-5158952-A | 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-10-27 | — | — | US | claimed |