Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 18/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.57 |
| ▸ | KIT | P10721 | 8/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.57 |
| ▸ | FLT3 | P36888 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2675471 | 0.93 | CSF1R (0.60) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL4368847 | 0.90 | CSF1R (0.66) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2676241 | 0.90 | CSF1R (0.58) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2675951 | 0.89 | CSF1R (0.62) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL4547446 | 0.88 | CSF1R (0.58) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2676898 | 0.88 | CSF1R (0.59) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2678035 | 0.88 | CSF1R (0.61) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2676708 | 0.87 | CSF1R (0.60) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2677342 | 0.87 | CSF1R (0.64) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2678002 | 0.87 | CSF1R (0.62) | CSF1RPDGFRBKITPDGFRAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553854-B2 | 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2009-06-30 | — | — | US | claimed |