Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | COMT | P21964 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12673399 | 0.85 | TSHR (0.52) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL29700226 | 0.84 | TSHR (0.66) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL28346073 | 0.84 | TSHR (0.66) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL28250596 | 0.84 | ALDH1A1 (0.54) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL519134 | 0.78 | TSHR (0.67) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL19259817 | 0.77 | TSHR (0.71) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL10616071 | 0.77 | TSHR (0.71) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL5342056 | 0.77 | TSHR (0.71) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL14489596 | 0.77 | TSHR (0.71) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL14818738 | 0.77 | TSHR (0.71) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907399-B1 | 5,6-DI-SUBSTITUTED OXADIAZOLOPYRAZINES AND THIADIAZOLOPYRAZINES AS CXC-CHEMOKINE RECEPTOR LIGANDS | SCHERING CORP (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7498338-B2 | Compounds | ASTRAZENECA AB (SE) | 2009-03-03 | — | — | US | disclosed |
| US-20070129393-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2007-06-07 | — | — | US | disclosed |
| EP-1687311-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005049620-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129393-A1 | Novel compounds | C1R, CHRM1, CHRM2 | TSHR 155/4885CYP2C9 811/4885CYP2C19 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.