Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PGD | P52209 | 2/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL4778934 | 0.85 | TSHR (0.83) | TSHRTP53NFKB1CYP2C19CYP2C9 | |
| Cadaverine Tartrate SCHEMBL8945831 | 0.85 | TSHR (0.83) | TSHRTP53NFKB1CYP2C19CYP2C9 | |
| Tartaric Acid SCHEMBL5762 | 0.84 | TSHR (1.00) | TSHRTP53NFKB1CYP2C19CYP2C9 | |
| Cadaverine Tartrate SCHEMBL1062721 | 0.84 | TSHR (1.00) | TSHRTP53NFKB1CYP2C19CYP2C9 | |
| Cadaverine Tartrate SCHEMBL31427568 | 0.84 | TSHR (1.00) | TSHRTP53NFKB1CYP2C19CYP2C9 | |
| Cadaverine Tartrate SCHEMBL22768 | 0.84 | TSHR (1.00) | TSHRTP53NFKB1CYP2C19CYP2C9 | |
| Cadaverine Tartrate SCHEMBL116846 | 0.84 | TSHR (1.00) | TSHRTP53NFKB1CYP2C19CYP2C9 | |
| Cadaverine Tartrate SCHEMBL1431070 | 0.84 | TSHR (1.00) | TSHRTP53NFKB1CYP2C19CYP2C9 | |
| Cadaverine Tartrate SCHEMBL848 | 0.84 | TSHR (1.00) | TSHRTP53NFKB1CYP2C19CYP2C9 | |
| Tartaric Acid SCHEMBL29430365 | 0.84 | TSHR (1.00) | TSHRTP53NFKB1CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090292018-A1 | Dicarbonic Acid Derivatives, Metastasis Inhibitors and Agents Increasing Chemotherapeutic Activity of Anti-Tumor Preparations, Method for Enhancing the Cytostatic Efficiency and Metastasis Process Inhibiting Method | INSTITUT PROBLEM KHIMICHESKOI FITZIKI ROSSIISKOI AKADEMII NAUK (RU) | 2009-11-26 | — | — | US | disclosed |
| US-20080214671-A1 | Dicarbonic Acid Derivatives, Metastasis Inhibitors and Agents Increasing Chemotherapeutic Activity of Anti-Tumor Preparations, Method for Enhancing the Cytostatic Efficiency and Metastasis Process Inhibiting Method | INSTITUT PROBLEM KHIMICHESKOI FIZIKI ROSSIISKOI AKADEMII NAUK (RU) | 2008-09-04 | — | — | US | disclosed |
| EP-1894916-A2 | DICARBONIC ACID DERIVATIVES, METASTASIS INHIBITORS AND AGENTS INCREASING CHEMOTHERAPEUTIC ACTIVITY OF ANTI-TUMOR PREPARATIONS, METHOD FOR ENHANCING THE EFFICIENCY OF CYTOSTATICS AND METASTASIS PROCESS INHIBITING METHOD | Institut Problem Khimicheskoi Fiziki Rossiiskoi AK (RU) | 2008-03-05 | — | — | EP | disclosed |
| US-4782005-A | N,N'-diorgano dicarboxamides as oxygen inhibitors in radiation sensitive acrylate compositions | POLYCHROME CORP. (US) | 1988-11-01 | — | — | US | disclosed |