Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 11/20 | 0.47 |
| ▸ | AURKA | O14965 | 11/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | BCR | P11274 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 2/20 | 0.43 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.43 |
| ▸ | STK25 | O00506 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4362432 | 1.00 | AURKB (0.47) | AURKBAURKAABL1BCRHDAC3 | |
| SCHEMBL4363095 | 0.99 | AURKB (0.47) | AURKBAURKAABL1BCRHDAC3 | |
| SCHEMBL4370921 | 0.97 | AURKB (0.48) | AURKBAURKAABL1BCRHDAC3 | |
| SCHEMBL13785844 | 0.87 | AURKB (0.60) | AURKBAURKAABL1BCRNTRK1 | |
| SCHEMBL13785499 | 0.86 | AURKB (0.61) | AURKBAURKAABL1BCRNTRK1 | |
| SCHEMBL1954399 | 0.86 | AURKA (0.59) | AURKBAURKAABL1BCRNTRK1 | |
| SCHEMBL13785849 | 0.84 | AURKB (0.62) | AURKBAURKAABL1BCRNTRK1 | |
| SCHEMBL4367230 | 0.83 | AURKA (0.57) | AURKBAURKAABL1BCRNTRK1 | |
| SCHEMBL4362898 | 0.83 | AURKB (0.39) | AURKBAURKAHDAC1HDAC2HDAC6 | |
| SCHEMBL2713050 | 0.83 | AURKA (0.57) | AURKBAURKAABL1BCRNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009086012-A1 | AURORA INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |