SCHEMBL4369891

SCHEMBL4369891

CC(C)COc1ccc(C(=O)NC(Cc2ccc(OC(C)C)cc2)C(=O)NCCO)cc1

nearest known ligand 0.56

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CTSS P25774 11/20 0.56
CTSL P07711 9/20 0.56
L3MBTL1 Q9Y468 1/20 0.47
KMT2A Q03164 1/20 0.46
CTSK P43235 3/20 0.46
NR1H4 Q96RI1 1/20 0.46
KLKB1 P03952 1/20 0.45
PLG P00747 1/20 0.45
GAA P10253 1/20 0.43
RAB9A P51151 1/20 0.43
ACACB O00763 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13620366 0.86 CTSS (0.54) CTSSCTSLL3MBTL1KMT2ACTSK
SCHEMBL13631848 0.79 KLKB1 (0.55) CTSLL3MBTL1KMT2AKLKB1PLG
SCHEMBL4367178 0.78 KLKB1 (0.55) CTSSCTSLL3MBTL1CTSKNR1H4
SCHEMBL4370281 0.77 CTSS (0.50) CTSSCTSLL3MBTL1KMT2ACTSK
SCHEMBL4374886 0.77 KMT2A (0.48) CTSSCTSLL3MBTL1KMT2AKLKB1
SCHEMBL4376004 0.77 CTSS (0.50) CTSSCTSLL3MBTL1KMT2ACTSK
SCHEMBL4364899 0.77 KMT2A (0.48) CTSSCTSLL3MBTL1KMT2AKLKB1
SCHEMBL13620369 0.77 KLKB1 (0.54) CTSSCTSLL3MBTL1CTSKNR1H4
SCHEMBL15478871 0.77 CTSS (0.48) CTSSCTSLL3MBTL1KMT2ACTSK
SCHEMBL4368079 0.77 CTSS (0.51) CTSSCTSLKMT2ACTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1908466-B1 SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME DAIICHI SANKYO CO LTD (JP) 2014-02-19 EP disclosed
US-8344029-B2 Substituted propanamide derivative and pharmaceutical composition containing the same DAIICHI SANKYO COMPANY, LIMITED (JP) 2013-01-01 US disclosed
US-8344029-B2 Substituted propanamide derivative and pharmaceutical composition containing the same DAIICHI SANKYO COMPANY, LIMITED (JP) 2013-01-01 US disclosed
US-8344029-B2 Substituted propanamide derivative and pharmaceutical composition containing the same DAIICHI SANKYO COMPANY, LIMITED (JP) 2013-01-01 US disclosed
US-20090292024-A1 SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-11-26 US disclosed
US-20090292024-A1 SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-11-26 US disclosed
US-20090292024-A1 SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-11-26 US disclosed
EP-1908466-A1 SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME Daiichi Sankyo Company, Limited (JP) 2008-04-09 EP disclosed
EP-1908466-A1 SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME Daiichi Sankyo Company, Limited (JP) 2008-04-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090292024-A1 SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME PTMS, C1S, ACP3 CTSS 416/4885CTSL 530/4885L3MBTL1 3162/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.