Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.39 |
| ▸ | CCR3 | P51677 | 3/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1074588 | 0.96 | ALK (0.42) | HTTKDM4ELMNAMAPK1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4361197 | 0.94 | ALK (0.37) | LMNASMN1; SMN2HSD17B10ALK | |
| Trifluoroacetic Acid SCHEMBL4365019 | 0.92 | ALK (0.40) | SMN1; SMN2ALKP2RY12FAAHGSK3B | |
| Trifluoroacetic Acid SCHEMBL4364725 | 0.92 | ALK (0.40) | HTTKDM4ELMNASMN1; SMN2ALK | |
| Trifluoroacetic Acid SCHEMBL4365232 | 0.92 | ALK (0.39) | LMNASMN1; SMN2ALKFAAH | |
| Trifluoroacetic Acid SCHEMBL4365045 | 0.91 | ALK (0.39) | HTTLMNASMN1; SMN2HSD17B10ALK | |
| Trifluoroacetic Acid SCHEMBL4354068 | 0.90 | FAAH (0.40) | ALKFAAHPDGFRB | |
| Trifluoroacetic Acid SCHEMBL4360423 | 0.90 | ALK (0.38) | KDM4ELMNAALK | |
| SCHEMBL13632938 | 0.90 | CCR3 (0.39) | HTTKDM4ELMNAMAPK1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4354516 | 0.90 | ALK (0.39) | MAPK1SMN1; SMN2HSD17B10ALKP2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | HTT 2476/4885KDM4E 248/4885LMNA 4393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.