SCHEMBL4370586

SCHEMBL4370586

NCc1ccc(Oc2ccc(F)cc2F)cc1

nearest known ligand 0.54

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HSPB1 P04792 2/20 0.54
ST14 Q9Y5Y6 3/20 0.53
MAOB P27338 5/20 0.50
LOXL2 Q9Y4K0 1/20 0.50
ROCK2 O75116 1/20 0.47
ROCK1 Q13464 1/20 0.47
SCN4A P35499 1/20 0.45
AR P10275 1/20 0.44
NR3C1 P04150 1/20 0.44
TAAR1 Q96RJ0 1/20 0.43
TRPA1 O75762 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL765629 0.83 ST14 (0.50) ST14MAOBROCK2ROCK1
SCHEMBL12239024 0.83 ST14 (0.50) ST14MAOBROCK2ROCK1TAAR1
SCHEMBL12239036 0.83 ST14 (0.50) ST14MAOBLOXL2NR3C1TAAR1
SCHEMBL13904298 0.83 MAOB (0.50) HSPB1ST14MAOBLOXL2ROCK2
SCHEMBL4367987 0.83 ST14 (0.50) ST14MAOBLOXL2ROCK2ROCK1
SCHEMBL12967549 0.83 HSPB1 (0.54) HSPB1ARNR3C1TRPA1
SCHEMBL6157137 0.83 HSPB1 (0.54) HSPB1SCN4AARNR3C1TRPA1
SCHEMBL507282 0.82 MAOB (0.56) ST14MAOBLOXL2
Hydrochloric Acid SCHEMBL922861 0.81 MAOB (0.57) ST14MAOBLOXL2
Water SCHEMBL920135 0.81 MAOB (0.54) ST14MAOBLOXL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009117421-A2 HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE KALYPSYS, INC. (US) 2009-09-24 WO disclosed
WO-2009117421-A2 HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE KALYPSYS, INC. (US) 2009-09-24 WO disclosed