Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 4/20 | 0.56 |
| ▸ | KDR | P35968 | 9/20 | 0.55 |
| ▸ | AURKA | O14965 | 6/20 | 0.55 |
| ▸ | TEK | Q02763 | 6/20 | 0.55 |
| ▸ | LCK | P06239 | 5/20 | 0.55 |
| ▸ | MET | P08581 | 5/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.55 |
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | AXL | P30530 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4367074 | 0.93 | MET (0.60) | PDGFRAKDRAURKATEKLCK | |
| SCHEMBL1474508 | 0.92 | KMT2A (0.61) | PDGFRAKDRAURKATEKLCK | |
| SCHEMBL1471406 | 0.86 | MAPT (0.69) | PDGFRAKDRAURKATEKLCK | |
| SCHEMBL4369659 | 0.85 | AXL (0.53) | PDGFRAKDRAURKATEKLCK | |
| SCHEMBL1472160 | 0.85 | RET (0.58) | PDGFRAKDRAURKATEKLCK | |
| SCHEMBL12750537 | 0.85 | RET (0.58) | PDGFRAKDRAURKATEKLCK | |
| SCHEMBL1472232 | 0.84 | KDR (0.58) | PDGFRAKDRAURKATEKLCK | |
| SCHEMBL1474621 | 0.84 | KDR (0.58) | PDGFRAKDRAURKATEKLCK | |
| SCHEMBL1472127 | 0.84 | RET (0.59) | PDGFRAKDRAURKATEKLCK | |
| SCHEMBL1472072 | 0.84 | RET (0.61) | PDGFRAKDRAURKATEKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125780-A1 | SUBSTITUTED HETEROCYCLES AND METHODS OF USE | Amgen Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079294-A1 | SUBSTITUTED HETEROCYCLES AND METHODS OF USE | AMGEN INC. (US) | 2008-07-03 | — | — | WO | disclosed |