Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | PRNP | P04156 | 2/20 | 0.55 |
| ▸ | MTOR | P42345 | 2/20 | 0.55 |
| ▸ | APP | P05067 | 2/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | NQO2 | P16083 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377782 | 0.93 | CHRM2 (0.52) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL16568037 | 0.84 | NR4A2 (0.46) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL16568038 | 0.81 | KCNH2 (0.61) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL4369951 | 0.80 | NR4A2 (0.43) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL30026121 | 0.79 | NR4A2 (0.44) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL8539820 | 0.74 | NR4A2 (0.47) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL4374933 | 0.73 | NR4A2 (0.46) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL3018921 | 0.73 | CHRM2 (0.49) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL1147580 | 0.72 | CHRM2 (0.61) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL26355647 | 0.72 | CHRM2 (0.64) | CHRM2CHRM4CHRM5ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009148659-A2 | ANTIMALARIAL QUINOLINES AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2009-12-10 | — | — | WO | disclosed |