SCHEMBL4370973

SCHEMBL4370973

O=[N+]([O-])c1ccc(C=Cc2nc(NCCCN3CCCC3)c3cc(F)ccc3n2)o1

nearest known ligand 0.55

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
FLT3 P36888 17/20 0.55
MELK Q14680 1/20 0.45
ACP1 P24666 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4370967 1.00 FLT3 (0.55) FLT3MELKACP1
SCHEMBL4886376 0.94 FLT3 (0.50) FLT3MELKACP1
SCHEMBL4886383 0.94 FLT3 (0.50) FLT3MELKACP1
SCHEMBL14167789 0.85 FLT3 (0.56) FLT3MELKACP1
SCHEMBL4885754 0.85 FLT3 (0.41) FLT3MELK
SCHEMBL4369838 0.85 FLT3 (0.41) FLT3MELK
SCHEMBL4364191 0.84 FLT3 (0.44) FLT3MELKACP1
SCHEMBL14167507 0.79 FLT3 (0.51) FLT3MELKACP1
SCHEMBL4365949 0.76 MAPT (0.44) FLT3
SCHEMBL4365944 0.76 MAPT (0.44) FLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009046536-A1 HALOGENATED QUINAZOLINYL NITROFURANS AS ANTIBACTERIAL AGENTS ULYSSES PHARMACEUTICAL PRODUCTS, INC. (CA) 2009-04-16 WO disclosed
US-20080146562-A1 HALOGENATED QUINAZOLINYL NITROFURANS AS ANTIBACTERIAL AGENTS ULYSSES PHARMACEUTICAL PRODUCTS INC., 2008-06-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080146562-A1 HALOGENATED QUINAZOLINYL NITROFURANS AS ANTIBACTERIAL AGENTS HRH3, HRH1, NQO2 FLT3 1868/4885MELK 4706/4885ACP1 4375/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.