Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 9/20 | 0.72 |
| ▸ | CTSS | P25774 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | CTSV | O60911 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371066 | 1.00 | CTSK (0.72) | CTSKCTSSALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4371059 | 1.00 | CTSK (0.72) | CTSKCTSSALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5942128 | 1.00 | CTSK (0.72) | CTSKCTSSALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4375538 | 0.93 | CTSK (0.80) | CTSKCTSSCCR1CTSLCTSV | |
| SCHEMBL4375532 | 0.93 | CTSK (0.80) | CTSKCTSSCCR1CTSLCTSV | |
| SCHEMBL5941645 | 0.93 | CTSK (0.80) | CTSKCTSSCCR1CTSLCTSV | |
| SCHEMBL4375530 | 0.93 | CTSK (0.80) | CTSKCTSSCCR1CTSLCTSV | |
| SCHEMBL5942142 | 0.92 | CTSK (0.62) | CTSKCTSSALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5942144 | 0.92 | CTSK (0.62) | CTSKCTSSALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5941948 | 0.92 | CTSK (0.82) | CTSKCTSSALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |