Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.37 |
| ▸ | CDK9 | P50750 | 7/20 | 0.37 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.36 |
| ▸ | PIP4K2B | P78356 | 3/20 | 0.36 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377531 | 0.95 | PIP4K2C (0.42) | PIP4K2CCYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL28527047 | 0.92 | CCNT1 (0.39) | PIP4K2CCYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL1243768 | 0.89 | PIP4K2C (0.42) | PIP4K2CCYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL4375143 | 0.88 | PIP4K2C (0.43) | PIP4K2CCYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL1244508 | 0.85 | CCNT1 (0.39) | PIP4K2CCYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL4378384 | 0.83 | RET (0.38) | PIP4K2CCYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL4375779 | 0.83 | PIP4K2C (0.50) | PIP4K2CCYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL1244273 | 0.83 | PIP4K2C (0.43) | PIP4K2CCYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL1244828 | 0.83 | PIP4K2C (0.42) | PIP4K2CCYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL1243893 | 0.82 | PIP4K2C (0.51) | PIP4K2CCYP1A2CYP2D6CYP2C19CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763526-B1 | 4,6-DISUBSTITUTED PYRIMIDINES AND THEIR USE AS PROTEIN KINASE INHIBITORS | BAYER SCHERING PHARMA AG (DE) | 2009-06-24 | — | — | EP | claimed |