Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 3/20 | 0.45 |
| ▸ | PGR | P06401 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | KAT2B | Q92831 | 15/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548066 | 0.89 | NR3C1 (0.47) | NR3C1PGRARKAT2BMEN1 | |
| SCHEMBL3529867 | 0.85 | NR3C1 (0.50) | NR3C1PGRAR | |
| SCHEMBL4378770 | 0.82 | NR3C1 (0.40) | NR3C1PGRARKAT2BMEN1 | |
| SCHEMBL4370800 | 0.80 | NR3C1 (0.42) | NR3C1PGRARKAT2BMEN1 | |
| SCHEMBL3532756 | 0.77 | NR3C1 (0.75) | NR3C1PGRAR | |
| SCHEMBL3534714 | 0.76 | NR3C1 (0.47) | NR3C1PGRAR | |
| SCHEMBL3534090 | 0.76 | NR3C1 (0.49) | NR3C1PGRAR | |
| SCHEMBL4536811 | 0.75 | NR3C1 (0.44) | NR3C1PGRARKAT2BMEN1 | |
| SCHEMBL3535385 | 0.74 | NR3C1 (0.53) | NR3C1PGRAR | |
| SCHEMBL331548 | 0.72 | NR3C1 (0.53) | NR3C1PGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7638515-B2 | improved selectivity and pharmacokinetic properties; 6-Fluoro-1-[(1 H-indazol-4-yl)amino]-4,4-dimethyl-2-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalene-2,5-diol; cyclization of imines | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-12-29 | — | — | US | claimed |