Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 8/20 | 0.58 |
| ▸ | ADAM10 | O14672 | 7/20 | 0.58 |
| ▸ | MMP2 | P08253 | 7/20 | 0.58 |
| ▸ | MMP9 | P14780 | 7/20 | 0.58 |
| ▸ | MMP14 | P50281 | 5/20 | 0.58 |
| ▸ | ADAM8 | P78325 | 4/20 | 0.57 |
| ▸ | MMP12 | P39900 | 3/20 | 0.57 |
| ▸ | MMP1 | P03956 | 2/20 | 0.52 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.52 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.52 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.52 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.52 |
| ▸ | BMP1 | P13497 | 10/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4293039 | 0.92 | ADAM17 (0.48) | ADAM17ADAM10MMP2MMP9MMP14 | |
| SCHEMBL3874554 | 0.89 | ADAM17 (0.51) | ADAM17ADAM10MMP2MMP9MMP14 | |
| SCHEMBL14470899 | 0.88 | ADAM17 (0.50) | ADAM17ADAM10MMP2MMP9MMP14 | |
| SCHEMBL1799334 | 0.88 | ADAM17 (0.50) | ADAM17ADAM10MMP2MMP9MMP14 | |
| SCHEMBL1799058 | 0.88 | ADAM17 (0.54) | ADAM17ADAM10MMP2MMP9MMP14 | |
| SCHEMBL12619375 | 0.87 | ADAM17 (0.49) | ADAM17ADAM10MMP2MMP9MMP14 | |
| SCHEMBL1800584 | 0.87 | ADAM17 (0.49) | ADAM17ADAM10MMP2MMP9MMP14 | |
| SCHEMBL4374580 | 0.84 | ADAM17 (0.45) | ADAM17ADAM10MMP2MMP9MMP14 | |
| SCHEMBL1800730 | 0.82 | ADAM17 (0.44) | ADAM17ADAM10MMP2MMP9MMP14 | |
| SCHEMBL4371681 | 0.82 | ADAM17 (0.49) | ADAM17ADAM10MMP2MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |