Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | GIPR | P48546 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846091 | 0.88 | EGLN3 (0.64) | EGLN3PTGDR2KMT2A | |
| SCHEMBL3846045 | 0.87 | ALDH1A1 (0.45) | EGLN3PTGDR2KMT2AADORA1ADORA3 | |
| SCHEMBL3849163 | 0.79 | PTGDR2 (0.50) | PTGDR2KMT2AADORA1ADORA3PTGER4 | |
| SCHEMBL3846989 | 0.78 | EGLN1 (0.57) | EGLN3PTGDR2PTGER4 | |
| SCHEMBL3854700 | 0.76 | MAPK1 (0.50) | ADORA1ADORA3ADORA2AKDM4ECHRNA7 | |
| SCHEMBL3845670 | 0.74 | EGLN1 (0.50) | EGLN3ADORA1ADORA3ADORA2ACNR2 | |
| SCHEMBL3849218 | 0.73 | SMN1; SMN2 (0.45) | KMT2AADORA1ADORA3ADORA2AKDM4E | |
| SCHEMBL3848043 | 0.72 | EGLN3 (0.48) | EGLN3ADORA1ADORA3CNR2 | |
| SCHEMBL3849583 | 0.67 | SMN1; SMN2 (0.48) | KMT2AKDM4ECNR2 | |
| SCHEMBL3846940 | 0.67 | EGLN3 (0.72) | EGLN3PTGDR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124565-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008089052-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |