Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.54 |
| ▸ | CDK9 | P50750 | 4/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 8/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.50 |
| ▸ | CLK1 | P49759 | 4/20 | 0.49 |
| ▸ | CLK2 | P49760 | 4/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372901 | 1.00 | CDK2 (0.54) | CDK2CDK9CCNE1CCNE2CCNA2 | |
| SCHEMBL4372753 | 0.85 | CDK2 (0.49) | CDK2CCNE1CCNE2CCNA2CDK1 | |
| SCHEMBL4372748 | 0.85 | CDK2 (0.49) | CDK2CCNE1CCNE2CCNA2CDK1 | |
| SCHEMBL4373952 | 0.84 | CDK2 (0.49) | CDK2CDK9CCNE1CCNE2CCNA2 | |
| SCHEMBL4377640 | 0.83 | CDK2 (0.56) | CDK2CDK9CCNE1CCNE2CCNA2 | |
| SCHEMBL4375080 | 0.83 | CDK2 (0.56) | CDK2CDK9CCNE1CCNE2CCNA2 | |
| SCHEMBL20549619 | 0.83 | CDK5 (0.52) | CDK2CDK9CCNE1CCNE2CCNA2 | |
| SCHEMBL22388794 | 0.83 | CDK5 (0.52) | CDK2CDK9CCNE1CCNE2CCNA2 | |
| SCHEMBL20549618 | 0.83 | CDK5 (0.52) | CDK2CDK9CCNE1CCNE2CCNA2 | |
| SCHEMBL4372504 | 0.82 | MERTK (0.39) | CDK2CCNA2FLT3CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377579-B1 | ACYL AND SULFONYL DERIVATIVES OF 6,9-DISUBSTITUTED 2-(TRANS-1,4-DIAMINOCYCLOHEXYL)-PURINES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS | AVENTIS PHARMA INC (US) | 2009-03-25 | — | — | EP | disclosed |
| US-7429595-B2 | Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents | AVENTIS PHARMACEUTICALS INC. (US) | 2008-09-30 | — | — | US | disclosed |
| US-6861524-B2 | Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents | AVENTIS PHARMACEUTICALS INC. (US) | 2005-03-01 | — | — | US | disclosed |
| US-20040248908-A1 | Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents | AVENTIS PHARMACEUTICALS INC. | 2004-12-09 | — | — | US | disclosed |
| EP-1377579-A2 | ACYL AND SULFONYL DERIVATIVES OF 6,9-DISUBSTITUTED 2-(TRANS-1,4-DIAMINOCYCLOHEXYL)-PURINES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS | Aventis Pharmaceuticals Inc. (US) | 2004-01-07 | — | — | EP | disclosed |
| US-20030069259-A1 | Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents | AVENTISUB LLC | 2003-04-10 | — | — | US | disclosed |
| WO-2002042303-A2 | ACYL AND SULFONYL DERIVATIVES OF 6,9-DISUBSTITUTED 2-(TRANS-1,4-DIAMINOCYCLOHEXYL)-PURINES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS | AVENTIS PHARMACEUTICALS INC. (US) | 2002-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069259-A1 | Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents | BAD, BAX, MCL1 | CDK2 167/4885CDK9 204/4885CCNE1 1465/4885 |
| US-20040248908-A1 | Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents | TYMP, TK1, SLC29A1 | CDK2 68/4885CDK9 254/4885CCNE1 314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.