Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 9/20 | 0.73 |
| ▸ | GSK3B | P49841 | 9/20 | 0.73 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.73 |
| ▸ | CDC42BPA | Q5VT25 | 8/20 | 0.73 |
| ▸ | CSNK1G3 | Q9Y6M4 | 8/20 | 0.73 |
| ▸ | PRKACA | P17612 | 7/20 | 0.73 |
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.73 |
| ▸ | RPS6KA3 | P51812 | 7/20 | 0.73 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.73 |
| ▸ | PRKG1 | Q13976 | 7/20 | 0.73 |
| ▸ | CHEK2 | O96017 | 7/20 | 0.73 |
| ▸ | PKN2 | Q16513 | 7/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.73 |
| ▸ | HIPK4 | Q8NE63 | 6/20 | 0.73 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.73 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.73 |
| ▸ | SGK2 | Q9HBY8 | 5/20 | 0.73 |
| ▸ | CSNK1G2 | P78368 | 5/20 | 0.73 |
| ▸ | CSNK1G1 | Q9HCP0 | 5/20 | 0.73 |
| ▸ | NEK4 | P51957 | 4/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376451 | 0.85 | MAPKAPK2 (0.85) | GSK3AGSK3BROCK1CDC42BPACSNK1G3 | |
| SCHEMBL4374703 | 0.85 | ROCK1 (1.00) | GSK3AGSK3BROCK1CDC42BPACSNK1G3 | |
| SCHEMBL4030799 | 0.84 | FLT4 (0.78) | GSK3AGSK3BROCK1CDC42BPACSNK1G3 | |
| SCHEMBL4026608 | 0.83 | GSK3A (0.85) | GSK3AGSK3BROCK1CDC42BPACSNK1G3 | |
| SCHEMBL4370778 | 0.82 | GSK3A (1.00) | GSK3AGSK3BROCK1CDC42BPACSNK1G3 | |
| SCHEMBL4369926 | 0.82 | ROCK1 (0.74) | GSK3AGSK3BROCK1CDC42BPACSNK1G3 | |
| SCHEMBL4368914 | 0.82 | ROCK1 (0.74) | GSK3AGSK3BROCK1CDC42BPACSNK1G3 | |
| SCHEMBL4375983 | 0.81 | MAPKAPK2 (1.00) | GSK3AGSK3BROCK1CDC42BPACSNK1G3 | |
| SCHEMBL4378368 | 0.81 | ROCK1 (0.73) | GSK3AGSK3BROCK1CDC42BPACSNK1G3 | |
| SCHEMBL4024345 | 0.80 | PRKACA (0.79) | GSK3AGSK3BROCK1CDC42BPACSNK1G3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | claimed |