Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 4/20 | 0.53 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3588838 | 0.88 | FFAR1 (0.53) | KLKB1NFKB1PSMB5NFKB2RELA | |
| SCHEMBL3588585 | 0.88 | KLKB1 (0.57) | MMP2KLKB1NFKB1PSMB5NFKB2 | |
| SCHEMBL2246373 | 0.87 | HTT (0.67) | MMP2HTTADAMTS5MMP8MMP12 | |
| SCHEMBL3589157 | 0.87 | KLKB1 (0.50) | MMP2KLKB1NFKB1PSMB5NFKB2 | |
| SCHEMBL3583762 | 0.87 | CTSS (0.53) | MMP2KLKB1HTTNFKB1PSMB5 | |
| SCHEMBL3583723 | 0.86 | KLKB1 (0.54) | MMP2KLKB1NPC1RAB9AADAMTS5 | |
| SCHEMBL3584887 | 0.85 | KLKB1 (0.69) | MMP2KLKB1L3MBTL1NPC1RAB9A | |
| SCHEMBL2251666 | 0.85 | NPC1 (0.67) | MMP2KLKB1NPC1RAB9AADAMTS5 | |
| SCHEMBL3595965 | 0.84 | KLKB1 (0.53) | MMP2KLKB1NPC1RAB9AADAMTS5 | |
| SCHEMBL3577147 | 0.84 | KLKB1 (0.56) | MMP2KLKB1HTTNFKB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | claimed |