Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2606491 | 0.90 | SMN1; SMN2 (0.42) | SMN1; SMN2RAB9ADHFREGFRL3MBTL1 | |
| SCHEMBL4370345 | 0.88 | SMN1; SMN2 (0.44) | SMN1; SMN2RAB9ADHFREGFRACHE | |
| SCHEMBL998735 | 0.83 | L3MBTL1 (0.52) | SMN1; SMN2RAB9AL3MBTL1ALDH1A1TSHR | |
| SCHEMBL999303 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2RAB9ADHFREGFRACHE | |
| SCHEMBL1001793 | 0.81 | GCK (0.45) | SMN1; SMN2RAB9AITGB3ITGA2BEGLN2 | |
| SCHEMBL1002363 | 0.80 | SMN1; SMN2 (0.42) | SMN1; SMN2RAB9ADHFREGFRL3MBTL1 | |
| SCHEMBL1002364 | 0.80 | SMN1; SMN2 (0.42) | SMN1; SMN2RAB9ADHFREGFRL3MBTL1 | |
| SCHEMBL16136774 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9ADHFREGFRL3MBTL1 | |
| SCHEMBL2606477 | 0.78 | CNR1 (0.47) | SMN1; SMN2RAB9AALDH1A1NPC1GAA | |
| SCHEMBL998640 | 0.76 | SMN1; SMN2 (0.71) | SMN1; SMN2RAB9AEGFRALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598391-B2 | Heteroaryl-ureas and their use as glucokinase activators | NOVO NORDISK A/S (DK) | 2009-10-06 | — | — | US | disclosed |