Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 10/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | SORD | Q00796 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CA3 | P07451 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14185644 | 0.88 | HIF1A (0.45) | HIF1ASMN1; SMN2TP53CES2CES1 | |
| SCHEMBL692254 | 0.88 | HIF1A (0.45) | HIF1ASMN1; SMN2TP53CES2CES1 | |
| SCHEMBL11208465 | 0.71 | HIF1A (0.44) | HIF1ASMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL11202946 | 0.71 | HIF1A (0.46) | HIF1ASMN1; SMN2TP53CA12CA1 | |
| SCHEMBL5294295 | 0.70 | HIF1A (0.45) | HIF1ASMN1; SMN2TP53CA12CA1 | |
| SCHEMBL9689288 | 0.69 | FAAH (0.46) | HIF1ASMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL11211934 | 0.68 | HIF1A (0.43) | HIF1ASMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL753859 | 0.67 | HIF1A (0.42) | HIF1ASMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL4983840 | 0.67 | HIF1A (0.42) | HIF1ASMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL8663680 | 0.66 | ESR1 (0.42) | HIF1ASMN1; SMN2NPC1RAB9ASORD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750696-A4 | RESISTANCE-REPELLENT RETROVIRAL PROTEASE INHIBITORS | SEQUOIA PHARMACEUTICALS INC (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1750696-A2 | RESISTANCE-REPELLENT RETROVIRAL PROTEASE INHIBITORS | SEQUOIA PHARMACEUTICALS, INC. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005110428-A2 | RESISTANCE-REPELLENT RETROVIRAL PROTEASE INHIBITORS | SEQUOIA PHARMACEUTICALS, INC. (US) | 2005-11-24 | — | — | WO | disclosed |