Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 14/20 | 0.65 |
| ▸ | BCHE | P06276 | 7/20 | 0.65 |
| ▸ | ACHE | P22303 | 7/20 | 0.65 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.61 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.61 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.61 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.61 |
| ▸ | RECQL | P46063 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | THPO | P40225 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4368882 | 1.00 | CHRM2 (0.65) | CHRM2BCHEACHECHRM4CHRM5 | |
| SCHEMBL4205563 | 1.00 | CHRM2 (0.65) | CHRM2BCHEACHECHRM4CHRM5 | |
| SCHEMBL4203774 | 0.99 | CHRM2 (0.63) | CHRM2BCHEACHECHRM4CHRM5 | |
| SCHEMBL4380661 | 0.96 | CHRM2 (0.60) | CHRM2BCHEACHECHRM4CHRM5 | |
| SCHEMBL4366616 | 0.92 | CD274 (0.58) | CHRM2BCHEACHEGRIN1GRIN2A | |
| SCHEMBL13876824 | 0.86 | CHRM2 (0.57) | CHRM2BCHEACHEMAPTSMN1; SMN2 | |
| SCHEMBL4365743 | 0.84 | TGM2 (0.58) | CHRM2BCHEACHESMN1; SMN2 | |
| SCHEMBL3067744 | 0.84 | HTT (0.67) | CHRM2BCHEACHESMN1; SMN2 | |
| SCHEMBL4373055 | 0.84 | HTT (0.67) | CHRM2BCHEACHESMN1; SMN2 | |
| SCHEMBL13706605 | 0.82 | MEN1 (0.58) | CHRM2BCHEMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589219-B2 | 2,5-bis-diamine-[1,4]benzoquinonic derivatives, useful for the treatment of alzheimer's disease, method for preparing them and intermediates of said method | ALMA MATER STUDIORUM-UNIVERSITA' DI BOLOGNA (IT) | 2009-09-15 | — | — | US | disclosed |
| US-7589219-B2 | 2,5-bis-diamine-[1,4]benzoquinonic derivatives, useful for the treatment of alzheimer's disease, method for preparing them and intermediates of said method | ALMA MATER STUDIORUM-UNIVERSITA' DI BOLOGNA (IT) | 2009-09-15 | — | — | US | disclosed |
| US-20050261345-A1 | 2,5-Bis-diamine-'1,4! benzoquinone derivatives, for the treatment of alzheimer's disease a process for their preparation and intermediates therefor | ALMA MATER STUDIORUM-UNIVERSITA' DI BOLOGNA (IT) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261345-A1 | 2,5-Bis-diamine-'1,4! benzoquinone derivatives, for the treatment of alzheimer's disease a process for their preparation and intermediates therefor | PSEN2, BACE2, WEE2 | CHRM2 1909/4885BCHE 77/4885ACHE 169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.