Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 18/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 16/20 | 0.66 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372207 | 0.80 | PTGS1 (1.00) | PTGS1PTGS2SLC22A12 | |
| SCHEMBL4381246 | 0.75 | PTGS1 (1.00) | PTGS1PTGS2SLC22A12 | |
| SCHEMBL4381220 | 0.75 | PTGS1 (1.00) | PTGS1PTGS2SLC22A12 | |
| SCHEMBL4372692 | 0.74 | PTGS1 (0.80) | PTGS1PTGS2SLC22A12 | |
| SCHEMBL4380993 | 0.74 | PTGS1 (1.00) | PTGS1PTGS2 | |
| SCHEMBL28898093 | 0.69 | SLC22A12 (0.75) | PTGS1PTGS2SLC22A12 | |
| SCHEMBL4377183 | 0.68 | MGMT (0.37) | PTGS1PTGS2 | |
| SCHEMBL31061517 | 0.67 | PTGS1 (0.76) | PTGS1PTGS2SLC22A12 | |
| SCHEMBL28452434 | 0.67 | SLC22A12 (1.00) | PTGS1PTGS2SLC22A12 | |
| SCHEMBL16389095 | 0.66 | PTGS1 (0.56) | PTGS1PTGS2SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432684-B1 | PYRIDINIC SULFONAMIDE DERIVATIVES, METHOD OF PRODUCTION AND USE THEREOF | UNIV LIEGE (BE) | 2009-03-25 | — | — | EP | disclosed |
| US-20070173534-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | UNIVERSITE DE LIEGE | 2007-07-26 | — | — | US | disclosed |
| US-7226936-B2 | Pyridinic sulfonamide derivatives method of production and use thereof | UNIVERSITY DE LIEGE (BE) | 2007-06-05 | — | — | US | disclosed |
| US-20050020642-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | UNIVERSITE DE LIEGE (BE) | 2005-01-27 | — | — | US | disclosed |
| EP-1432684-A2 | PYRIDINIC SULFONAMIDE DERIVATIVES, METHOD OF PRODUCTION AND USE THEREOF | University of Liege (BE) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003029217-A2 | PYRIDINIC SULFONAMIDE DERIVATIVES, METHOD OF PRODUCTION AND USE THEREOF | UNIVERSITE DE LIEGE (BE) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173534-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | PTGIS, ARSA, C3AR1 | PTGS1 4/4885PTGS2 13/4885SLC22A12 2984/4885 |
| US-20050020642-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | ARSA, PTGIS, C3AR1 | PTGS1 4/4885PTGS2 31/4885SLC22A12 3008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.