Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethylformamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylformamide SCHEMBL5360 | 0.86 | — | — | |
| Dimethylformamide SCHEMBL23532600 | 0.86 | TSHR (0.64) | TSHR | |
| Dimethylformamide SCHEMBL746068 | 0.86 | TSHR (0.64) | TSHR | |
| Dimethylformamide SCHEMBL333489 | 0.86 | — | — | |
| Dimethylformamide SCHEMBL731136 | 0.86 | — | — | |
| Dimethylformamide SCHEMBL28144582 | 0.83 | TSHR (0.60) | TSHR | |
| Dimethylformamide SCHEMBL11211737 | 0.80 | TSHR (0.56) | TSHR | |
| Dimethylformamide SCHEMBL17748325 | 0.80 | TSHR (0.56) | TSHR | |
| Dimethylformamide SCHEMBL4931100 | 0.77 | TSHR (0.45) | TSHR | |
| Dimethyl Sulfoxide SCHEMBL10004118 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1219180-B1 | Cancer chemoprotective food products | UNIV JOHNS HOPKINS MED (US) | 2009-11-11 | — | — | EP | claimed |
| US-7303770-B2 | Cancer chemoprotective food products | JOHNS HOPKINS SCHOOL OF MEDICINE (US) | 2007-12-04 | — | — | US | claimed |
| CN-109311933-A | The method for preparing farnesol X receptor stimulating agent | 迪法玛弗朗西斯有限公司 | 2019-02-05 | — | — | CN | disclosed |
| CN-1036007-Y | Pyrrole and imidazole and imidazole compound and pyridine base substituted by 1 hour benzimidazole derivatives | Janssen medicine industry co ltd | 1997-10-01 | — | — | CN | disclosed |