SCHEMBL4375414

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL27402094	0.90	TSHR (0.76)	TSHRKMT2AMEN1CYP2C9CYP2C19
	SCHEMBL4378529	0.86	ALDH1A1 (0.62)	TSHRKMT2ACYP2C9CYP2C19MAPT
	SCHEMBL4378341	0.85	HTT (0.76)	TSHRKMT2AMEN1CYP2C9CYP2C19
	Hydrochloric Acid SCHEMBL4382890	0.85	ALDH1A1 (0.61)	TSHRKMT2ACYP2C9CYP2C19MAPT
	SCHEMBL4379305	0.83	KMT2A (0.65)	TSHRKMT2AMEN1CYP2C9MAPT
	SCHEMBL4379063	0.83	KDM4E (0.82)	TSHRCYP2C9CYP2C19MAPTHTT
	SCHEMBL4377632	0.82	MAPK1 (0.75)	TSHRKMT2AMEN1CYP2C9CYP2C19
	SCHEMBL4376079	0.81	MEN1 (0.77)	TSHRKMT2AMEN1MAPTHTT
	SCHEMBL4382063	0.81	HTT (0.63)	TSHRKMT2AMEN1CYP2C9CYP2C19
	SCHEMBL791659	0.79	KMT2A (0.71)	TSHRKMT2AMEN1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.