Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 13/20 | 0.69 |
| ▸ | BCR | P11274 | 11/20 | 0.69 |
| ▸ | PRKCA | P17252 | 3/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.63 |
| ▸ | EGFR | P00533 | 4/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.59 |
| ▸ | BTK | Q06187 | 1/20 | 0.59 |
| ▸ | ITK | Q08881 | 1/20 | 0.59 |
| ▸ | KIT | P10721 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378896 | 0.89 | ABL1 (0.69) | ABL1BCRPRKCAPDGFRAPDGFRB | |
| SCHEMBL12320924 | 0.84 | ABL1 (0.78) | ABL1BCRPRKCAPDGFRAPDGFRB | |
| SCHEMBL4892544 | 0.82 | KIT (0.69) | ABL1BCRPRKCAPDGFRAPDGFRB | |
| SCHEMBL2392 | 0.82 | ABL1 (1.00) | ABL1BCRPRKCAPDGFRAPDGFRB | |
| SCHEMBL29555505 | 0.82 | ABL1 (1.00) | ABL1BCRPRKCAPDGFRAPDGFRB | |
| SCHEMBL29366999 | 0.82 | ABL1 (1.00) | ABL1BCRPRKCAPDGFRAPDGFRB | |
| SCHEMBL29005835 | 0.82 | ABL1 (0.75) | ABL1BCRPRKCAPDGFRAPDGFRB | |
| SCHEMBL3210634 | 0.82 | ABL1 (0.75) | ABL1BCRPRKCAPDGFRAPDGFRB | |
| SCHEMBL30359587 | 0.82 | ABL1 (0.75) | ABL1BCRPRKCAPDGFRAPDGFRB | |
| SCHEMBL18560357 | 0.82 | ABL1 (0.75) | ABL1BCRPRKCAPDGFRAPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009109991-A2 | NOVEL HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD., (IN) | 2009-09-11 | — | — | WO | disclosed |
| WO-2009109991-A2 | NOVEL HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD., (IN) | 2009-09-11 | — | — | WO | disclosed |