Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11568465 | 0.79 | — | — | |
| SCHEMBL17444431 | 0.72 | TSHR (0.42) | ALDH1A1TSHRTDP1 | |
| SCHEMBL981371 | 0.72 | TSHR (0.42) | ALDH1A1TSHR | |
| SCHEMBL6939659 | 0.70 | TSHR (0.46) | TSHR | |
| SCHEMBL11248018 | 0.70 | TSHR (0.39) | ALDH1A1TSHRTDP1 | |
| SCHEMBL9698734 | 0.70 | TSHR (0.46) | TSHR | |
| SCHEMBL6932074 | 0.70 | TSHR (0.46) | TSHR | |
| SCHEMBL2679887 | 0.70 | TSHR (0.46) | TSHR | |
| SCHEMBL1176786 | 0.69 | — | — | |
| SCHEMBL50560 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038272-A2 | PYRIDINONYL PDK1 INHIBITORS | Sunesis Pharmaceuticals, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008005457-A2 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHARMACEUTICALS (US) | 2008-01-10 | — | — | WO | disclosed |