Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.40 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31682182 | 0.87 | SSTR4 (0.39) | SLC6A2SLC6A4SLC6A3CYP2D6OPRM1 | |
| SCHEMBL4372327 | 0.84 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3CYP2D6ATM | |
| SCHEMBL2172656 | 0.84 | ATM (0.57) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL31682199 | 0.83 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL8135217 | 0.83 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL1919144 | 0.82 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL4632632 | 0.82 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| Hydrochloric Acid SCHEMBL6543165 | 0.81 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5810068 | 0.81 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| Hydrochloric Acid SCHEMBL8762583 | 0.80 | LMNA (0.41) | MEN1KMT2AOPRM1SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101678064-B | Methods of treating or preventing emesis using growth hormone secretagogues | HELSINN HEALTHCARE S.A. (CH) | 2016-03-16 | — | — | CN | disclosed |
| CN-101678064-A | Methods of treating or preventing emesis using growth hormone secretagogues | SAPPHIRE THERAPEUTICS INC | 2010-03-24 | — | — | CN | disclosed |
| EP-1077941-B1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2009-08-12 | — | — | EP | disclosed |
| US-6303620-B1 | USED FOR THERAPY OF MEDICAL DISORDERS RESULTING FROM A DEFICIENCY IN GROWTH HORMONE | NOVO NORDISK A/S (DK) | 2001-10-16 | — | — | US | disclosed |
| EP-1077941-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | Novo Nordisk A/S (DK) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058501-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1999-11-18 | — | — | WO | disclosed |