Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 19/20 | 0.88 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.77 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.77 |
| ▸ | PDE2A | O00408 | 1/20 | 0.77 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.77 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.77 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.77 |
| ▸ | BRD4 | O60885 | 1/20 | 0.77 |
| ▸ | PDE5A | O76074 | 1/20 | 0.77 |
| ▸ | TP53 | P04637 | 1/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.77 |
| ▸ | PIM1 | P11309 | 1/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.77 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12522821 | 0.91 | PRKDC (1.00) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3CD | |
| SCHEMBL12452457 | 0.90 | PRKDC (0.82) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3CD | |
| SCHEMBL29557073 | 0.88 | PRKDC (0.80) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3CD | |
| SCHEMBL13700043 | 0.88 | PRKDC (0.80) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3CD | |
| Ly-294002 SCHEMBL94377 | 0.87 | PRKDC (1.00) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3CD | |
| Ly-294002 SCHEMBL29424167 | 0.87 | PRKDC (1.00) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3CD | |
| SCHEMBL31060584 | 0.86 | PRKDC (1.00) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3CD | |
| SCHEMBL4418721 | 0.86 | PRKDC (0.80) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3CD | |
| SCHEMBL31061281 | 0.86 | PRKDC (1.00) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3CD | |
| SCHEMBL12452458 | 0.86 | PRKDC (0.80) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11254671-B2 | Chemical compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-02-22 | — | — | US | disclosed |
| US-20210163472-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-06-03 | — | — | US | disclosed |
| EP-2406258-B1 | PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | CELLZOME LTD (GB) | 2014-12-03 | — | — | EP | disclosed |
| US-20140296234-A1 | PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED | 2014-10-02 | — | — | US | disclosed |
| US-8785457-B2 | Pyrimidine derivatives as mTOR inhibitors | CELLZOME LIMITED (GB) | 2014-07-22 | — | — | US | disclosed |
| US-20120065202-A1 | PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | CELLZOME LIMITED (GB) | 2012-03-15 | — | — | US | disclosed |
| EP-2410062-A1 | Selectivity profiling of PI3K interacting molecules against multiple targets | CELLZOME AG (DE) | 2012-01-25 | — | — | EP | disclosed |
| EP-2410062-A1 | Selectivity profiling of PI3K interacting molecules against multiple targets | CELLZOME AG (DE) | 2012-01-25 | — | — | EP | disclosed |
| EP-2406258-A1 | PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | Cellzome Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| EP-2245181-B1 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS | CELLZOME AG (DE) | 2011-10-12 | — | — | EP | disclosed |
| EP-2245181-B1 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS | CELLZOME AG (DE) | 2011-10-12 | — | — | EP | disclosed |
| US-20110111972-A1 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS | CELLZOME AG (DE) | 2011-05-12 | — | — | US | disclosed |
| US-20110111972-A1 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS | CELLZOME AG (DE) | 2011-05-12 | — | — | US | disclosed |
| EP-2245181-A1 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS | CELLZOME AG (DE) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010103094-A1 | PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | CELLZOME LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |
| WO-2009098021-A1 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS | CELLZOME AG (DE) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065202-A1 | PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | PRKDC 559/4885KDM4E 1225/4885ALDH1A1 3397/4885 |
| US-20140296234-A1 | PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | MTOR, RICTOR, RPTOR | PRKDC 559/4885KDM4E 1225/4885ALDH1A1 3397/4885 |
| US-20210163472-A1 | CHEMICAL COMPOUNDS | MTOR, RICTOR, RPTOR | PRKDC 1138/4885KDM4E 983/4885ALDH1A1 2417/4885 |
| US-11254671-B2 | Chemical compounds | MTOR, RICTOR, RPTOR | PRKDC 1138/4885KDM4E 983/4885ALDH1A1 2417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.