Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377267 | 1.00 | SLC6A4 (0.55) | SLC6A4SLC6A3HRH3SLC6A2MEN1 | |
| Hydrochloric Acid SCHEMBL4375762 | 0.99 | SLC6A4 (0.54) | SLC6A4SLC6A3HRH3SLC6A2MEN1 | |
| Hydrochloric Acid SCHEMBL4378691 | 0.99 | SLC6A4 (0.54) | SLC6A4SLC6A3HRH3SLC6A2MEN1 | |
| SCHEMBL4381663 | 0.81 | ALDH1A1 (0.51) | MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL4381660 | 0.81 | ALDH1A1 (0.51) | MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL13636030 | 0.80 | HRH3 (0.46) | SLC6A4SLC6A3HRH3MEN1POLB | |
| Hydrochloric Acid SCHEMBL4376444 | 0.80 | ALDH1A1 (0.50) | HRH3MEN1KMT2AHPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL4376442 | 0.80 | ALDH1A1 (0.50) | HRH3MEN1KMT2AHPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL4375748 | 0.79 | HRH3 (0.46) | SLC6A4SLC6A3HRH3MEN1POLB | |
| Hydrochloric Acid SCHEMBL4375745 | 0.79 | HRH3 (0.46) | SLC6A4SLC6A3HRH3MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | claimed |
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |
| US-7208497-B2 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2007-04-24 | — | — | US | disclosed |