Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.61 |
| ▸ | KDR | P35968 | 8/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.61 |
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | LCK | P06239 | 2/20 | 0.61 |
| ▸ | LYN | P07948 | 2/20 | 0.61 |
| ▸ | RET | P07949 | 2/20 | 0.61 |
| ▸ | HCK | P08631 | 2/20 | 0.61 |
| ▸ | BCR | P11274 | 2/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.61 |
| ▸ | FLT3 | P36888 | 2/20 | 0.61 |
| ▸ | ABL2 | P42684 | 2/20 | 0.61 |
| ▸ | FRK | P42685 | 2/20 | 0.61 |
| ▸ | MST1R | Q04912 | 2/20 | 0.61 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.61 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.61 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.61 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.61 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2248716 | 0.91 | MET (0.72) | METKDRNTRK1RIPK2ABL1 | |
| SCHEMBL3553069 | 0.87 | KDR (0.63) | METKDRNTRK1RIPK2ABL1 | |
| SCHEMBL3555758 | 0.84 | MET (0.63) | METKDRNTRK1RIPK2ABL1 | |
| SCHEMBL2251439 | 0.83 | MET (0.65) | METKDRNTRK1RIPK2ABL1 | |
| SCHEMBL2252302 | 0.83 | MET (0.60) | METKDRNTRK1RIPK2ABL1 | |
| SCHEMBL2255402 | 0.83 | MET (0.60) | METKDRNTRK1RIPK2ABL1 | |
| SCHEMBL2255553 | 0.82 | MET (0.61) | METKDRNTRK1RIPK2ABL1 | |
| SCHEMBL2254741 | 0.82 | MET (0.60) | METKDRNTRK1RIPK2ABL1 | |
| SCHEMBL2249540 | 0.81 | MET (0.58) | METKDRNTRK1RIPK2ABL1 | |
| SCHEMBL3553749 | 0.81 | MET (0.55) | METKDRNTRK1RIPK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119706-A1 | PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE | Eisai R&D Management Co., Ltd. (JP) | 2009-11-18 | — | — | EP | claimed |