Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1677845 | 0.99 | P2RX7 (0.47) | P2RX7SMN1; SMN2ALDH1A1CYP19A1CYP17A1 | |
| SCHEMBL1678436 | 0.90 | P2RX7 (0.51) | P2RX7SMN1; SMN2ALDH1A1CYP19A1CYP17A1 | |
| Hydrochloric Acid SCHEMBL1677912 | 0.89 | P2RX7 (0.50) | P2RX7SMN1; SMN2ALDH1A1CYP19A1CYP17A1 | |
| SCHEMBL1678665 | 0.88 | P2RX7 (0.49) | P2RX7SMN1; SMN2ALDH1A1CYP19A1CYP17A1 | |
| SCHEMBL1678506 | 0.87 | P2RX7 (0.46) | P2RX7SMN1; SMN2ALDH1A1CYP19A1CYP17A1 | |
| SCHEMBL1679345 | 0.87 | P2RX7 (0.48) | P2RX7SMN1; SMN2ALDH1A1CYP19A1CYP17A1 | |
| Hydrochloric Acid SCHEMBL1678038 | 0.86 | P2RX7 (0.46) | P2RX7SMN1; SMN2ALDH1A1CYP19A1CYP17A1 | |
| SCHEMBL1678533 | 0.86 | P2RX7 (0.47) | P2RX7SMN1; SMN2ALDH1A1CYP19A1CYP17A1 | |
| SCHEMBL1677703 | 0.85 | P2RX7 (0.46) | P2RX7SMN1; SMN2ALDH1A1CYP19A1CYP17A1 | |
| SCHEMBL1677980 | 0.85 | P2RX7 (0.46) | P2RX7SMN1; SMN2ALDH1A1CYP19A1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1743885-B1 | 1-[(adamantyl)alkyl]-3-[(pyridinyl)alkyl]urea compounds as TNF-.alpha inhibitors useful for autoimmune diseases | SANTEN PHARMACEUTICAL CO LTD (JP) | 2009-11-11 | — | — | EP | disclosed |
| EP-1743885-A2 | TNF-Alpha Produktion Hemmer zur Behandlung von Autoimmunerkrankungen | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2007-01-17 | — | — | EP | disclosed |