⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL761123 | 1.00 | — | — | |
| SCHEMBL14749839 | 1.00 | — | — | |
| Ammonia Solution, Strong SCHEMBL2888472 | 0.98 | GABRP (0.42) | — | |
| SCHEMBL11299879 | 0.98 | GABRP (0.42) | — | |
| Hexadecane SCHEMBL8144910 | 0.85 | SLC5A1 (0.46) | — | |
| Decane SCHEMBL8084226 | 0.85 | SLC5A1 (0.46) | — | |
| SCHEMBL16118869 | 0.81 | — | — | |
| SCHEMBL2047186 | 0.79 | — | — | |
| SCHEMBL16139775 | 0.79 | — | — | |
| SCHEMBL14750309 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 569 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025202864-A1 | ENT1 INHIBITORS IN COMBINATION WITH ONCOLYTIC VIRUSES AND THEIR USE IN THE TREATMENT OF CANCER | iTeos Belgium SA (BE) | 2025-10-02 | — | — | WO | claimed |
| WO-2025126110-A1 | ENT1 INHIBITORS IN COMBINATION WITH BISPECIFIC ANTIBODIES | iTeos Belgium SA (BE) | 2025-06-19 | — | — | WO | claimed |
| WO-2025104613-A1 | ENT1 INHIBITORS IN COMBINATION WITH CHECKPOINT INHIBITORS | iTeos Belgium SA (BE) | 2025-05-22 | — | — | WO | claimed |
| CN-115197115-B | Preparation method and application of chiral 5-oxo pyrrolidine-3-carboxylic acid | 成都金博汇康医药科技有限公司 | 2024-11-08 | — | — | CN | claimed |
| CN-117285702-A | PBAT copolyester with adjustable degradation rate in water and preparation method thereof | 康辉新材料科技有限公司 | 2023-12-26 | — | — | CN | claimed |
| CN-116535365-A | Macrocyclic diamine derivatives and their combination with adenosine receptor antagonists as ENT inhibitors for the treatment of cancer | ITEOS比利时公司 | 2023-08-04 | — | — | CN | claimed |
| CN-115028819-B | Method for preparing clothes-kang acid-based dipyrrolidone dicarboxylic acid and related polyester thereof | 大连大学 | 2023-07-04 | — | — | CN | claimed |
| US-20230203058-A1 | MACROCYCLIC DIAMINE DERIVATIVES AS ENT INHIBITORS FOR THE TREATMENT OF CANCERS, AND COMBINATION THEREOF WITH ADENOSINE RECEPTOR ANTAGONISTS | iTeos Belgium SA (BE) | 2023-06-29 | — | — | US | claimed |
| EP-4132933-A1 | MACROCYCLIC DIAMINE DERIVATIVES AS ENT INHIBITORS FOR THE TREATMENT OF CANCERS, AND COMBINATION THEREOF WITH ADENOSINE RECEPTOR ANTAGONISTS | iTeos Belgium SA (BE) | 2023-02-15 | — | — | EP | claimed |
| CN-115197115-A | Preparation method and application of chiral 5-oxopyrrolidine-3-formic acid | 成都金博汇康医药科技有限公司 | 2022-10-18 | — | — | CN | claimed |
| EP-2193782-A1 | Cosmetic composition comprising a dibenzoylmethane derivative and a 2-pyrrolidinone-4-carboxy ester compound; method for the photostabilization of the dibenzoylmethane derivative | L'Oreal (FR) | 2010-06-09 | — | — | EP | claimed |
| EP-2193783-A1 | Use of an ester derived from 4-carboxy-2-pyrrolidinone as a solvent in cosmetic compositions; cosmetic compositions containing same | L'Oreal (FR) | 2010-06-09 | — | — | EP | claimed |
| EP-2193784-A1 | Cosmetic compositions containing an ester derivative of 2-pyrrolidinone 4-carboxy and a lipophilic triazine filter, with use of said derivative as a solvent of a lipophilic triazine filter | L'OREAL (FR) | 2010-06-09 | — | — | EP | claimed |
| US-20080138301-A1 | Pyrrolidone-Carboxylic Modified Polysiloxanes Having Aqueous and Detergent Solubilities and Water-In-Oil Emulsion Capability | CRODA UNIQEMA INC. (US) | 2008-06-12 | — | — | US | claimed |
| EP-1765912-A1 | PYRROLIDONE-CARBOXYLIC MODIFIED POLYSILOXANES HAVING AQUEOUS AND DETERGENT SOLUBILITIES AND WATER-IN-OIL EMULSION CAPABILITY | Croda Uniqema Inc (US) | 2007-03-28 | — | — | EP | claimed |
| WO-2005111115-A1 | PYRROLIDONE-CARBOXYLIC MODIFIED POLYSILOXANES HAVING AQUEOUS AND DETERGENT SOLUBILITIES AND WATER-IN-OIL EMULSION CAPABILITY | CRODA UNIQEMA INC. (US) | 2005-11-24 | — | — | WO | claimed |
| EP-0909759-A2 | Individual stereoisomers of 7-(3-aminoalkyl)-1-pyrrolidinyl)-quinolones as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1999-04-21 | — | — | EP | claimed |
| US-5461165-A | Individual stereoisomers of intermediates of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1995-10-24 | — | — | US | claimed |
| EP-0559774-A1 | INDIVIDUAL STEREOISOMERS OF 7- 3-(1-AMINOALKYL)-1-PYRROLIDINYL]-QUINOLONES AND NAPHTHYRIDONES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-09-15 | — | — | EP | claimed |
| WO-1992009596-A1 | INDIVIDUAL STEREOISOMERS OF 7-[3-(1-AMINOALKYL)-1-PYRROLIDINYL]-QUINOLONES AND NAPHTHYRIDONES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-06-11 | — | — | WO | claimed |