Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.62 |
| ▸ | FLT4 | P35916 | 2/20 | 0.54 |
| ▸ | FES | P07332 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | AKT2 | P31751 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4365656 | 0.89 | FLT4 (0.65) | MAPKAPK2FLT4FESFGFR1KDR | |
| SCHEMBL4369661 | 0.86 | MAPKAPK2 (0.61) | MAPKAPK2FLT4FESFGFR1KDR | |
| SCHEMBL4379546 | 0.84 | MAPKAPK2 (0.59) | MAPKAPK2FLT4FESFGFR1KDR | |
| SCHEMBL4378403 | 0.83 | FES (0.52) | MAPKAPK2FLT4FESFGFR1KDR | |
| SCHEMBL4364173 | 0.80 | FLT4 (0.79) | MAPKAPK2FLT4FESFGFR1KDR | |
| SCHEMBL4368146 | 0.79 | CHEK1 (0.53) | MAPKAPK2FLT4FESFGFR1KDR | |
| SCHEMBL4366404 | 0.78 | FES (0.56) | MAPKAPK2FLT4FESFGFR1KDR | |
| SCHEMBL4370740 | 0.78 | FLT4 (0.56) | MAPKAPK2FLT4FESFGFR1KDR | |
| SCHEMBL16096866 | 0.78 | EGFR (0.50) | MAPKAPK2FLT4FESFGFR1KDR | |
| SCHEMBL4371065 | 0.77 | MAPKAPK2 (1.00) | MAPKAPK2CHEK2GSK3AGSK3BROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |