Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.59 |
| ▸ | FES | P07332 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | MST1R | Q04912 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | BUB1 | O43683 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ASPH | Q12797 | 1/20 | 0.42 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4365656 | 0.88 | FLT4 (0.65) | MAPKAPK2FESFGFR1FLT4KDR | |
| SCHEMBL4369661 | 0.85 | MAPKAPK2 (0.61) | MAPKAPK2FESFGFR1FLT4KDR | |
| SCHEMBL4378366 | 0.84 | MAPKAPK2 (0.62) | MAPKAPK2FESFGFR1FLT4KDR | |
| SCHEMBL4378403 | 0.84 | FES (0.52) | MAPKAPK2FESFGFR1FLT4KDR | |
| SCHEMBL4368146 | 0.83 | CHEK1 (0.53) | MAPKAPK2FESFGFR1FLT4KDR | |
| SCHEMBL4366404 | 0.82 | FES (0.56) | MAPKAPK2FESFGFR1FLT4KDR | |
| SCHEMBL4370740 | 0.82 | FLT4 (0.56) | MAPKAPK2FESFGFR1FLT4KDR | |
| SCHEMBL16096866 | 0.81 | EGFR (0.50) | MAPKAPK2FESFGFR1FLT4KDR | |
| SCHEMBL16095356 | 0.79 | FYN (0.44) | MAPKAPK2FESFGFR1FLT4KDR | |
| SCHEMBL16097036 | 0.79 | JAK3 (0.52) | MAPKAPK2FESFGFR1FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | claimed |
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |