Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3732356 | 0.91 | PTPN1 (0.49) | PTPN1HRH4KMOPIM1PIM3 | |
| SCHEMBL4382742 | 0.90 | HRH4 (0.42) | PTPN1HRH4ALDH1A1 | |
| SCHEMBL3732567 | 0.90 | PTPN1 (0.48) | PTPN1HRH4ALDH1A1KMOPIM1 | |
| SCHEMBL3732271 | 0.88 | PTPN1 (0.41) | PTPN1HRH4ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL3727498 | 0.84 | F2RL3 (0.33) | PTPN1HRH4PIM1PIM3PIM2 | |
| SCHEMBL4375700 | 0.83 | KDM4E (0.39) | PTPN1ALDH1A1 | |
| SCHEMBL4384856 | 0.81 | PTPN1 (0.39) | PTPN1PIM1PIM3PIM2 | |
| SCHEMBL3734371 | 0.79 | PDE2A (0.32) | PTPN1HRH4 | |
| SCHEMBL3746931 | 0.78 | CYP1A2 (0.33) | PTPN1ALDH1A1 | |
| SCHEMBL3732060 | 0.77 | PTPN1 (0.52) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |