Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 10/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 7/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.33 |
| ▸ | BPTF | Q12830 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3732356 | 0.87 | PTPN1 (0.49) | PTPN1PIM1PIM2PIM3 | |
| SCHEMBL3732567 | 0.86 | PTPN1 (0.48) | PTPN1PIM1PIM2PIM3 | |
| SCHEMBL4382742 | 0.82 | HRH4 (0.42) | PTPN1 | |
| SCHEMBL4378451 | 0.81 | PTPN1 (0.41) | PTPN1PIM1PIM2PIM3 | |
| SCHEMBL3732271 | 0.81 | PTPN1 (0.41) | PTPN1 | |
| SCHEMBL3727498 | 0.78 | F2RL3 (0.33) | PTPN1PIM1PIM2PIM3 | |
| SCHEMBL4375700 | 0.78 | KDM4E (0.39) | PTPN1 | |
| SCHEMBL3732060 | 0.74 | PTPN1 (0.52) | PTPN1 | |
| SCHEMBL3746931 | 0.73 | CYP1A2 (0.33) | PTPN1 | |
| SCHEMBL4386872 | 0.73 | MCHR1 (0.36) | PIM1PIM2PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |