⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL207868 | 1.00 | — | — | |
| Benzene SCHEMBL27854435 | 0.89 | FFAR3 (0.38) | — | |
| Methacrylic Acid SCHEMBL27535299 | 0.82 | TDP1 (0.43) | — | |
| SCHEMBL10417668 | 0.80 | TSHR (0.41) | — | |
| Acetone SCHEMBL28564801 | 0.78 | — | — | |
| SCHEMBL3439738 | 0.78 | — | — | |
| SCHEMBL25474034 | 0.75 | — | — | |
| Acetic Acid SCHEMBL28743669 | 0.75 | — | — | |
| SCHEMBL498258 | 0.75 | — | — | |
| SCHEMBL247472 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 191 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11505815-B2 | Compositions and methods related to non-templated enzymatic nucleic acid synthesis | NUCLERA NUCLEICS, LTD. (GB) | 2022-11-22 | — | — | US | claimed |
| CN-111072566-B | Preparation method and application of pyrazole derivative | 宿迁市科莱博生物化学有限公司 | 2022-02-08 | — | — | CN | claimed |
| EP-3710461-A1 | NUCLEOTIDE DERIVATIVES CONTAINING AMINE MASKED MOIETIES AND THEIR USE IN A TEMPLATED AND NON-TEMPLATED ENZYMATIC NUCLEIC ACID SYNTHESIS | Nuclera Nucleics Ltd (GB) | 2020-09-23 | — | — | EP | claimed |
| CN-111344296-A | Nucleotide derivatives containing amine-masked moieties and their use in templated and non-templated enzymatic nucleic acid synthesis | 核酸有限公司 | 2020-06-26 | — | — | CN | claimed |
| CN-111072566-A | Preparation method and application of pyrazole derivative | 宿迁市科莱博生物化学有限公司 | 2020-04-28 | — | — | CN | claimed |
| US-20190144905-A1 | Novel Use | Nuclera Nucleics Ltd. (GB) | 2019-05-16 | — | — | US | claimed |
| EP-2885276-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-06-01 | — | — | EP | claimed |
| US-9346763-B2 | Process for the preparation of pyrazole carboxylic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2016-05-24 | — | — | US | claimed |
| EP-2885276-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2015-06-24 | — | — | EP | claimed |
| US-20150158818-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-06-11 | — | — | US | claimed |
| CN-104540807-A | Process for the preparation of pyrazole carboxylic acid derivatives | HOFFMANN LA ROCHE | 2015-04-22 | — | — | CN | claimed |
| WO-2014027009-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-20 | — | — | WO | claimed |
| JP-4805909-B2 | — | — | 2011-11-02 | — | — | JP | claimed |
| US-20250388585-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES INC (US) | 2025-12-25 | — | — | US | disclosed |
| EP-4638436-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2025-10-29 | — | — | EP | disclosed |
| US-12448388-B2 | PRMT5 inhibitors and uses thereof | GILEAD SCIENCES, INC. (US) | 2025-10-21 | — | — | US | disclosed |
| US-4202892-A | FUNGICIDES, VIRICIDES, ANTIPROTOZOA AGENTS, PARKINSON'S DISEASE | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1980-05-13 | — | — | US | disclosed |
| EP-0002065-A1 | Methyladamantyl hydrazines, their pharmaceutically acceptable salts and pharmaceutical compositions containing them | Teva Pharmaceutical Industries Limited (IL) | 1979-05-30 | — | — | EP | disclosed |
| US-4045484-A | FROM ACETHYDRAZIDE, FORMALDEHYDE AND HYDROGEN IN A PALLADIUM CATALYST | UNIROYAL, INC. (US) | 1977-08-30 | — | — | US | disclosed |
| US-3931268-A | Methylhydrazinomethyl-substituted benzoic acid amides | HOFFMANN-LA ROCHE INC. (US) | 1976-01-06 | — | — | US | disclosed |