Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.70 |
| ▸ | CDK2 | P24941 | 13/20 | 0.70 |
| ▸ | SGK1 | O00141 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378696 | 1.00 | AKT1 (0.70) | AKT1CDK2SGK1 | |
| SCHEMBL4378689 | 1.00 | AKT1 (0.70) | AKT1CDK2SGK1 | |
| SCHEMBL4298558 | 0.93 | AKT1 (0.72) | AKT1CDK2SGK1 | |
| SCHEMBL4298561 | 0.93 | AKT1 (0.72) | AKT1CDK2SGK1 | |
| SCHEMBL4298553 | 0.93 | AKT1 (0.72) | AKT1CDK2SGK1 | |
| SCHEMBL4305561 | 0.88 | AKT1 (0.70) | AKT1CDK2SGK1 | |
| SCHEMBL4305552 | 0.88 | AKT1 (0.70) | AKT1CDK2SGK1 | |
| SCHEMBL4305565 | 0.88 | AKT1 (0.70) | AKT1CDK2SGK1 | |
| SCHEMBL4296878 | 0.88 | AKT1 (0.69) | AKT1CDK2SGK1 | |
| SCHEMBL4296882 | 0.88 | AKT1 (0.69) | AKT1CDK2SGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514566-B2 | Thiazole compounds and methods of use | AMGEN, INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-20070173506-A1 | Thiazole compounds and methods of use | AMGEN INC. (US) | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173506-A1 | Thiazole compounds and methods of use | MTOR, JAK2, PCK2 | AKT1 143/4885CDK2 62/4885SGK1 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.