Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7688715 | 0.78 | CCR1 (0.37) | POLBTSHRALDH1A1CCR1SMN1; SMN2 | |
| SCHEMBL4066969 | 0.78 | CCR1 (0.43) | POLBTSHRCCR1CYP2D6CYP2C9 | |
| SCHEMBL8285113 | 0.71 | POLB (0.58) | POLBTSHRGAANPSR1ALDH1A1 | |
| SCHEMBL3035554 | 0.71 | POLB (0.58) | POLBTSHRGAANPSR1ALDH1A1 | |
| SCHEMBL10253878 | 0.70 | GAA (0.60) | POLBTSHRGAANPSR1ALDH1A1 | |
| SCHEMBL4066963 | 0.70 | CTSC (0.35) | POLBTSHRALDH1A1CCR1SMN1; SMN2 | |
| SCHEMBL1107021 | 0.68 | GAA (0.62) | POLBTSHRGAANPSR1ALDH1A1 | |
| SCHEMBL4069074 | 0.68 | CCR1 (0.43) | POLBTSHRCCR1CYP2D6CYP2C9 | |
| SCHEMBL17152584 | 0.67 | TSHR (0.60) | POLBTSHRGAANPSR1ALDH1A1 | |
| SCHEMBL4069071 | 0.67 | CTSC (0.34) | POLBTSHRALDH1A1CCR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966443-B1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER (US) | 2009-01-28 | — | — | EP | disclosed |
| WO-2004039375-A1 | METHODS OF USING CCR1 ANTAGONISTS AS IMMUNOMODULATORY AGENTS | PFIZER PRODUCTS INC. (US) | 2004-05-13 | — | — | WO | disclosed |