Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | CTSC | P53634 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4066963 | 0.91 | CTSC (0.35) | CCR1POLBCTSCCYP2C19RAB9A | |
| SCHEMBL4069071 | 0.88 | CTSC (0.34) | CCR1POLBCTSCCYP2C19RAB9A | |
| SCHEMBL2676999 | 0.84 | RAB9A (0.37) | POLBCTSCCYP2C19RAB9ACYP3A4 | |
| SCHEMBL4066969 | 0.80 | CCR1 (0.43) | CCR1POLBCTSCCHRM2CCR5 | |
| SCHEMBL4066473 | 0.78 | CTSC (0.36) | CCR1POLBCTSCRAB9AALDH1A1 | |
| SCHEMBL4378739 | 0.78 | POLB (0.47) | CCR1POLBCYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7688073 | 0.77 | CCR1 (0.51) | CCR1CHRM2CCR5RIPK1ALDH1A1 | |
| SCHEMBL7686534 | 0.77 | CCR1 (0.41) | CCR1CHRM2CCR5ALDH1A1TSHR | |
| SCHEMBL7687929 | 0.76 | CCR1 (0.42) | CCR1CHRM2CCR5CYP1A2 | |
| SCHEMBL7686360 | 0.76 | CCR1 (0.41) | CCR1CHRM2CCR5L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | disclosed |