SCHEMBL437880

SCHEMBL437880

NCCC(=O)N1CC1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11032090 1.00 LMNA (0.56)
SCHEMBL4034610 0.91 LMNA (0.48)
SCHEMBL2682148 0.90 ATM (0.65)
SCHEMBL4034615 0.89 KMT2A (0.51)
SCHEMBL3920258 0.89 TDP1 (0.48)
SCHEMBL15224112 0.87 ATM (0.62)
Hydrochloric Acid SCHEMBL856723 0.87 ATM (0.62)
SCHEMBL6694116 0.87 ATM (0.62)
SCHEMBL2832300 0.87 ATM (0.62)
Hydrochloric Acid SCHEMBL4524439 0.87 TDP1 (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230346752-A1 PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING PURDUE RESEARCH FOUNDATION 2023-11-02 US disclosed
US-20230293497-A1 PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING PURDUE RESEARCH FOUNDATION (US) 2023-09-21 US disclosed
US-11717514-B2 PSMA binding ligand-linker conjugates and methods for using PURDUE RESEARCH FOUNDATION (US) 2023-08-08 US disclosed
US-9782493-B2 Conjugates for treating diseases caused by PSMA expressing cells ENDOCYTE, INC. (US) 2017-10-10 US disclosed
US-20170266303-A1 METHODS OF TREATING CANCER BY TARGETING TUMOR-ASSOCIATED MACROPHAGES PURDUE RESEARCH FOUNDATION 2017-09-21 US disclosed
US-20170258932-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE INC (US) 2017-09-14 US disclosed
US-20170151340-A1 Conjugates Containing Hydrophilic Spacer Linkers ENDOCYTE INC (US) 2017-06-01 US disclosed
US-9662402-B2 Drug delivery conjugates containing unnatural amino acids and methods for using ENDOCYTE, INC. (US) 2017-05-30 US disclosed
US-20160361376-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE, INC. 2016-12-15 US disclosed
US-20160361433-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE INC (US) 2016-12-15 US disclosed
US-20140058063-A1 VITAMIN RECEPTOR BINDING DRUG DELIVERY CONJUGATES ENDOCYTE, INC. (US) 2014-02-27 US disclosed
US-20130184435-A1 MULTI-DRUG LIGAND CONJUGATES ENDOCYTE, INC. (US) 2013-07-18 US disclosed
US-20130116195-A1 Binding ligand linked drug delivery conjugates of tubulysins LEAMON CHRISTOPHER PAUL (US) 2013-05-09 US disclosed
US-20120322741-A1 PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING PURDUE RESEARCH FOUNDATION (US) 2012-12-20 US disclosed
US-20120270791-A1 Methods and Compositions for Treating and Diagnosing Kidney Disease LEAMON CHRISTOPHER PAUL (US) 2012-10-25 US disclosed
US-20120065149-A1 Vitamin receptor binding drug delivery conjugates VLAHOV IONTCHO R (US) 2012-03-15 US disclosed
US-20120022245-A1 FOLATE TARGETING OF NUCLEOTIDES PURDUE RESEARCH FOUNDATION (US) 2012-01-26 US disclosed
US-20110288152-A1 PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING PURDUE RESEARCH FOUNDATION (US) 2011-11-24 US disclosed
US-20100323973-A1 CONJUGATES CONTAINING HYDROPHILIC SPACER LINKERS ENDOCTYE, INC. 2010-12-23 US disclosed
US-20100324008-A1 PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING PURDUE RESEARCH FOUNDATION (US) 2010-12-23 US disclosed