Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KHK | P50053 | 1/20 | 0.41 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2863889 | 0.76 | TTK (0.64) | TTKHDAC1THRBLMNAJAK2 | |
| SCHEMBL2862915 | 0.75 | TTK (0.68) | TTKHDAC1LMNANPSR1ALDH1A1 | |
| SCHEMBL2570957 | 0.72 | TTK (1.00) | TTKCYP2C9CYP3A4 | |
| SCHEMBL17514161 | 0.70 | MAP2K4 (0.47) | PARP1THRBJAK2JAK1ALDH1A1 | |
| SCHEMBL12281457 | 0.68 | TTK (0.90) | TTKCYP2C9CYP3A4 | |
| SCHEMBL6628661 | 0.67 | HDAC1 (0.71) | HDAC1THRBLMNANPSR1ALDH1A1 | |
| SCHEMBL27145740 | 0.67 | MEN1 (0.48) | PARP1ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL12741328 | 0.67 | CFTR (0.57) | TTKHDAC1THRBLMNANPSR1 | |
| SCHEMBL14404250 | 0.67 | ITK (0.60) | PARP1HAO1CDK2NPC1MAPT | |
| SCHEMBL7133357 | 0.67 | HTR2A (0.43) | PARP1JAK2JAK1NPSR1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |